Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Patent
1993-11-03
1996-04-23
Nutter, Nathan M.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
525 5421, 525 5422, 525 5423, 525 5424, C08G 6391
Patent
active
055104185
ABSTRACT:
Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluronic acid, the chondroitin sulfates, keratan sulfate, chitin and heparin, each of which is chemically derivatized to react with a hydrophilic synthetic polymer. The conjugate comprising a glycosaminoglycan covalently bound to a hydrophilic synthetic polymer may be further bound to collagen to form a three component conjugate having different properties. The hydrophilic synthetic polymer may be polyethylene glycol and derivatives thereof having an average molecular weight over a range of from about 100 to about 100,000. The compositions may include other components such as fluid, pharmaceutically acceptable carriers to form injectable formulations, and/or biologically active proteins such as growth factors or cytokines. The conjugates of the invention generally contain large amounts of water when formed. The conjugates can be dehydrated to form a relatively solid implant for use in hard tissue augmentation. The dehydrated, solid implant can further be ground into particles which can be suspended in a non-aqueous fluid and injected into a living being (preferably human) for soft tissue augmentation. Once in place, the solid implants or particles rehydrate and expand in size approximately three- to five-fold.
REFERENCES:
patent: 3619371 (1971-11-01), Crook et al.
patent: 3788948 (1974-01-01), Kagedal et al.
patent: 3876501 (1975-04-01), Hanushewsky
patent: 3949073 (1976-04-01), Daniels et al.
patent: 3960830 (1976-06-01), Bayer et al.
patent: 4002531 (1977-01-01), Royer
patent: 4055635 (1977-10-01), Green et al.
patent: 4088538 (1978-05-01), Schneider
patent: 4179337 (1979-12-01), Davis
patent: 4192021 (1980-03-01), Deibig et al.
patent: 4261973 (1981-04-01), Lee et al.
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4314380 (1982-02-01), Miyata et al.
patent: 4357274 (1982-11-01), Werner
patent: 4378017 (1983-03-01), Kosugi et al.
patent: 4412989 (1983-11-01), Iwashita et al.
patent: 4414147 (1983-11-01), Klibanov et al.
patent: 4415665 (1983-11-01), Mosbach et al.
patent: 4424208 (1984-01-01), Wallace et al.
patent: 4448718 (1984-05-01), Yannas et al.
patent: 4451397 (1984-05-01), Huc et al.
patent: 4451568 (1984-05-01), Schneider et al.
patent: 4488911 (1984-12-01), Luck et al.
patent: 4495285 (1985-01-01), Shimizu et al.
patent: 4496689 (1985-01-01), Mitra
patent: 4557764 (1985-12-01), Chu
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4563490 (1986-01-01), Stol et al.
patent: 4582640 (1986-04-01), Smestad et al.
patent: 4582865 (1986-04-01), Balazs et al.
patent: 4592864 (1986-06-01), Miyata et al.
patent: 4642117 (1987-02-01), Nguyen et al.
patent: 4678468 (1987-07-01), Hiroyoshi
patent: 4687820 (1987-08-01), Hou et al.
patent: 4689399 (1987-08-01), Chu
patent: 4703108 (1987-10-01), Silver et al.
patent: 4732863 (1988-03-01), Tomasi et al.
patent: 4737544 (1988-04-01), McCain et al.
patent: 4745180 (1988-05-01), Moreland et al.
patent: 4766106 (1988-08-01), Katre et al.
patent: 4828563 (1989-05-01), Muller-Lierhern
patent: 4847325 (1989-07-01), Shadle et al.
patent: 4935465 (1990-06-01), Garman
patent: 4937270 (1990-06-01), Hamilton et al.
patent: 4979959 (1990-12-01), Guire
patent: 5017229 (1991-05-01), Burns et al.
patent: 5099013 (1992-03-01), Balazs et al.
patent: 5128326 (1992-07-01), Balazs et al.
patent: 5137875 (1992-08-01), Tsunenaga et al.
patent: 5162430 (1992-11-01), Rhee et al.
patent: 5166187 (1992-11-01), Collombel et al.
patent: 5201764 (1993-04-01), Kelman et al.
patent: 5202431 (1993-04-01), della Valle et al.
patent: 5324775 (1994-06-01), Rhee et al.
07/907,518, Rhee et al., Jul. 2, 1992.
Abuchowski et al., "Cancer Therapy with Chemically Modified Enzymes. I. Antitumor Properties of Polyethylene Glycol-Asparaginase Conjugates," Cancer Biochem Biophys (1984) 7:175-86.
Balazs, E. A. et al., "Matrix Engineering," Blood Coagulation and Fibrinolysis (1991) 2:173-178.
Balazs, E. A. et al., "Clinical Uses of Hyaluronan," The Biology of Hyaluronan (1989) 265-285.
Bendich, A. et al., "Immunlogical Effects of Native and Polyethylene Glycol-Modified Asparaginases from Vibrio Succinogenes and Escherichia Coli in Normal and Tumour-Bearing Mice," Clin Exp Immunol (1982) 48: 273-78.
Chen, R. H. L. et al., "Properties of Two Urate Oxidases Modified by the Covalent Attachment of Poly(ethylene Glycol)," Biochim Biophys Acta (1981) 660:293-298.
Chvapil, M. et al., "Some Chemical and Biological Characteristics of a New Collagen-Polymer Compound Material," J. Biomed Mater Res (1969) 3:315-32.
Davis et al., "Hypouricaemic Effect of Polyethyleneglycol Modified Urate Oxidase," Lancet (1981) 2:281-83.
Doillon, C. J., et al., "Fibroblast Growth on a Porous Collagen Sponge Containing Hyaluronic Acid and Fibronectin," Biomaterials (1987) 8:195-200.
Inada et al., "Ester Synthesis Catalyzed by Polyethylene Glycol-Modified Lipase in Benzene," Biochem & Biophys Res Comm (1984) 122:845-50.
Lloyd et al., "Coupling of Acrylic Polymer and Collagen by Use of a Water-Soluble Carbodiimide," J Polymer Sci. Chem Ed. (1979) 17:3473-3483.
Nishida et al., "Hypouricaemic Effect after Oral Administration in Chickens of Polyethylene Glycol-Modified Uricase Entrapped in Liposomes," J. Pharm Pharmacol (1984) 36:354-355.
Pyatak, P. S. et al., "Preparation of a Polyethylene Glycol: Superoxide Dismutase Adduct, and an Examination of it Blood Circulating Life and Anti-Inflammatory Activity," Res Com Chem Path Pharmacol (1980) 29:113-27.
Ramshaw, J. A. M. et al., "Precipitation of Collagens by Polyethyelen Glycols," Anal Biochem (1984) 141:361-65.
Savoca, K. V. et al., "Preparation of a Non-immunogenic Arginase by the Covalent Attachment of Polyethylene Glycol," Biochem Biophys Acta (1979) 578: 47-53.
Takahashi et al., "A Chemical Modification to Make Horseradish Peroxidase Soluble and Active in Benzene," Biochem & Biophys Res Chem (1984) 121:261-65.
Viau, A. T. et al. "Safety Evaluation of Free Radical Scavengers PEG-Catalase and PEG-Superoxide Dismutase," J. Free Rad in Bio & Med (1986) 2:283-288.
Viau, A. T. et al. "Toxicologic Studies of a Conjugate of Asparaginase and Polyethylene Glycol in Mice, Rats, and Dogs," Am J Vet Res (1986) 47:1398.varies.401.
Wieder, K. J. et al., "Some Properties of Polyethylene Glycol: Phenylalanine Ammonia-Lyase Adducts," J Biol Chem (1979) 254: 12579-87.
Mizusawa, Atsushi, "Chitosan, Poly (vinyl alcohol) or Alginic Acid-Based Semipermeable membranes and Their Manufacture", Chemical Abstracts, vol. 121, No. 16, 17 Oct., 1994.
"Ointment for Pasting of Skin--includes Reaction Production of Polysaccharide Having Amino Group and Hydrophilic Polyfunctional Crosslinking Agent," DATABASE WPI, Section Ch, Week 8907, Derwent Publications Ltd., London, GB; Class A96, An 89-051979 & JP-A-64 003 116 (Nippon Oils & Fats KK), 6 Jan. 1989.
Berg Richard A.
Rhee Woonza M.
Church Shirley L.
Collagen Corporation
Nutter Nathan M.
Rafayko Kathi
LandOfFree
Glycosaminoglycan-synthetic polymer conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Glycosaminoglycan-synthetic polymer conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glycosaminoglycan-synthetic polymer conjugates will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2309048