Glycosaminoglycan-synthetic polymer conjugates

Details Glycosaminoglycan-synthetic polymer conjugates Glycosaminoglycan-synthetic polymer conjugates

1995-05-04

1996-04-23

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

424529, 424531, 424537, 424546, 424548, 424577, 424578, 424579, 424580, A61K 3512, A61K 3514, A61K 3524, A61K 3537

Patent

active

055101216

ABSTRACT:
Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluronic acid, the chondroitin sulfates, keratan sulfate, chitin and heparin, each of which is chemically derivatized to react with a hydrophilic synthetic polymer. The conjugate comprising a glycosaminoglycan covalently bound to a hydrophilic synthetic polymer may be further bound to collagen to form a three component conjugate having different properties. The hydrophilic synthetic polymer may be polyethylene glycol and derivatives thereof having an average molecular weight over a range of from about 100 to about 100,000. The compositions may include other components such as fluid, pharmaceutically acceptable carders to form injectable formulations, and/or biologically active proteins such as growth factors or cytokines. The conjugates of the invention generally contain large amounts of water when formed. The conjugates can be dehydrated to form a relatively solid implant for use in hard tissue augmentation. The dehydrated, solid implant can further be ground into particles which can be suspended in a non-aqueous fluid and injected into a living being (preferably human) for soft tissue augmentation. Once in place, the solid implants or particles rehydrate and expand in size approximately three- to five-fold.

REFERENCES:
patent: 5324775 (1994-06-01), Rhee et al.
Mizusawa, Atsushi, "Chitosan, Poly (vinyl alcohol) or Alginic Acid-Based Semipermeable membranes and Their Manufacture", Chemical Abstracts, vol. 121, No. 16, 17 Oct., 1994.
"Ointment for Pasting on Skin--Includes Reaction Production of Polysaccharide Having Amino Group and Hydrophilic Polyfunctional Crosslinkng Agent," Database WPI,, Section Ch, Week 8907, Derwent Publications Ltd., London, GB; An 89-051979 & JP-A-64 003 116 (Nippon Oils & Fats KK), 6 Jan. 1989.

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