Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1995-05-04
1995-12-19
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424486, 424488, 523113, 525937, A61F 200, A61K 914
Patent
active
054766664
ABSTRACT:
Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluronic acid, the chondroitin sulfates, keratan sulfate, chitin and heparin, each of which is chemically derivatized to react with a hydrophilic synthetic polymer. The conjugate comprising a glycosaminoglycan covalently bound to a hydrophilic synthetic polymer may be further bound to collagen to form a three component conjugate having different properties. The hydrophilic synthetic polymer may be polyethylene glycol and derivatives thereof having an average molecular weight over a range of from about 100 to about 100,000. The compositions may include other components such as fluid, pharmaceutically acceptable carriers to form injectable formulations, and/or biologically active proteins such as growth factors or cytokines. The conjugates of the invention generally contain large amounts of water when formed. The conjugates can be dehydrated to form a relatively solid implant for use in hard tissue augmentation. The dehydrated, solid implant can further be ground into particles which can be suspended in a non-aqueous fluid and injected into a living being (preferably human) for soft tissue augmentation. Once in place, the solid implants or particles rehydrate and expand in size approximately three- to five-fold.
REFERENCES:
patent: 5324775 (1994-06-01), Rhee et al.
I. Mizusawa, Atsushi, "Chitosan, Poly (vinyl alcohol) or Alginic Acid-Based Semipermeable membranes and Their Manufacture", Chemical Abstracts, vol. 121, No. 16, 17 Oct. 1994.
"Ointment for Pasting on Skin-includes Reaction Production of Polysaccharide Having Amino Group and Hydrophilic Polyfunctional Crosslinking Agent," Database WP1. Section Ch. Week 8907. Derwent Publications Ltd., London, GB; Class A96, An 89-051979 & JP-A-64 003 116 (Nippon Oils & Fats KK), 6 Jan. 1989.
Berg Richard A.
Rhee Woonza M.
Collagen Corporation
Nutter Nathan M.
Rafayko Kathi
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