Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-05-10
2005-05-10
Carlson, Karen Cochrane (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
06890899
ABSTRACT:
A biologically active lipid mobilizing agent for use in therapy is disclosed which has the properties and characteristics of a Zn-α2-glycoprotein, or of a fragment thereof having an apparent molecular mass Mrgreater than 6.0 kDa as determined by gel exclusion chromatography. Methods of isolation and purification from biological material are also disclosed together with uses of the material for making up pharmaceutical compositions, especially pharmaceutical compositions useful for treating mammals to achieve weight reduction or for controlling obesity. In addition, uses of the material for developing diagnostic agents and for identifying inhibitors of lipolytic activity for therapeutic purposes are disclosed.
REFERENCES:
Araki et al. Complete amino acid sequence of human Zn-alpha 2-glycoprotein and its homology to histocompatibility antigens. Proc Natl Acad Sci U S A. Feb. 1988;85(3):679-83.*
Ohkubo et al. Purification and characterization of human plasma Zn-alpha 2-glycoprotein. Prep Biochem. 1988;18(4):413-30.*
Hirai et al. Biological evaluation of a lipid-mobilizing factor isolated from the urine of cancer patients. Cancer Res. Jun. 1, 1998;58(11):2359-65.*
Sanchez et al: “Biochemical characterization and crystallization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog”, Proceedings of the National Academy of Sciences of USA, vol 94, no 9, Apr. 29, 1997, pp. 4626-4630, XP002127900, ISSN: 0027-8424.
Kitada et ak: “Characterization of a lipid mobilizing factor from tumors”, Chemical Abstracts, vol 96, no 21, May 24, 1982, abstract no 178891, XP002127902, & Prog. Lipid Res., vol 20, no 1-4, 1981, pp. 823-826.
Todorov et al: “Purification and characterization of a tumor lipid-mobilizing factor”, Cancer Research, vol 58, Jun. 1, 1998, pp. 2353-2358, XP002127901, ISSN: 0027-8424.
Tisdale Michael J
Todorov Penio T
Carlson Karen Cochrane
Snedden Sheridan K
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