Glycoproteins having lipid mobilising properties and...

Details Glycoproteins having lipid mobilising properties and... Glycoproteins having lipid mobilising properties and...

2004-08-16

2009-06-23

Monshipouri, Maryam (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07550429

ABSTRACT:
A biologically active lipid mobilising agent for use in therapy is disclosed which has the properties and characteristics of a Zn-α2-glycoprotein, or of a fragment thereof having an apparent molecular mass Mrgreater than 6.0 kDa as determined by gel exclusion chromatography. Methods of isolation and purification from biological material are also disclosed together with uses of the material for making up pharmaceutical compositions, especially pharmaceutical compositions useful for treating mammals to achieve weight reduction or for controlling obesity. In addition, uses of the material for developing diagnostic agents and for identifying inhibitors of lipolytic activity for therapeutic purposes are disclosed.

REFERENCES:
Araki, T., et al. 1988 PNAS 85: 679-683.
Sanchez, L.M., et al. 1997 PNAS 94: 4626-4630.
Burgi, W., et al. 1961 The Journal of Biological Chemistry 236(4): 1066-1074.
Hirai et al., “Mechanism of Depletion of Liver Glycogen in Cancer Cachexia,” Biochemical and Biophysical Research Communications, Academic Press, (241)p. 49-52, (1997).

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