Glycoproteinic conjugates having trivalent immunogenic activity

Details Glycoproteinic conjugates having trivalent immunogenic activity Glycoproteinic conjugates having trivalent immunogenic activity

1986-07-02

1987-12-08

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

530395, 530397, 530406, C07K 1710, A61K 39385

Patent

active

047117796

ABSTRACT:
Glycoproteinic conjugates having trivalent immunogenic activity obtained by binding, by a covalent bond, to a protein selected among CRM 197, tetanus toxoid, and pertussis toxin, at least an oligosaccharidic hapten derived from the capsular polysaccharide of a gram-positive bacterium and at least an oligosaccharidic hapten derived from the capsular polysaccharide of a gram-negative bacterium, and wherein said oligosaccharidic haptens are previously activated by introducing terminal esters.

REFERENCES:
patent: 4057685 (1977-11-01), McIntire
patent: 4356170 (1982-10-01), Jennings et al.
patent: 4496538 (1985-01-01), Gordon
patent: 4619828 (1986-10-01), Gordon
patent: 4663160 (1987-05-01), Tsay et al.
"An Immunological Study of the Diphtheria Toxin Molecule", A. M. Pappenheimer, Jr., et al., Immunchem., vol. 9, pp. 891-906 (1972).
"Diptheria Toxin and Related Proteins", T. Uchida, et al., J. Bio. Chem., vol. 248, No. 11, pp. 3838-3844 (1973).
"Pertussis Toxin", R. D. Sekura, et al., J. Bio. Chem., vol. 258, No. 23, pp. 14647-14651 (1983).
"Large-Scale Production of Tetanus Toxoid", P. A. Nielsen, J. App. Micro., pp. 453-454 (Mar. 1967).

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