Glycoprotein with antidiabetic, antihypertensive,...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.

Reexamination Certificate

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C530S350000, C530S412000, C530S414000, C530S417000, C530S418000, C530S424000, C514S008100, C514S866000, C514S909000, C426S049000, C426S615000, C426S655000

Reexamination Certificate

active

10762927

ABSTRACT:
A glycoprotein extracted from the fruiting body ofGrifola frondosais demonstrated to have antidiabetic, antihypertensive, antiobesity and antihyperlipidemic effects, and has great potential as an active component for pharmaceuticals, dietary supplements or health food preparations to treat and/or prevent the above diseases. This invention is to provide the glycoprotein and its preparation method.

REFERENCES:
patent: 5854404 (1998-12-01), Nanba et al.
Kusano et al., “Isolation of Antidiabetic Components from White-Skinned Sweet Potato (Ipomoea batatasL)”, Biosci. Biotechnol. Biochem., vol. 65, No. 1, pp. 109-114, 2001.
Keiko Kubo, Hisao Aoki, and Hiroaki Nanba. “Anti-diabetic Activity Present in the Fruit Body ofGrifola frondosa(Maitake). I”, Biol. Pharm. Bull., vol. 17, No. 8, 1994, pp. 1106-1110.
Hirotada Kurushima, Noriko Kodama and Hiroaki Nanba. “Activities of polysaccharides obtained fromGrifola frondosaon insulin-dependent diabetes mellitus induced by streptozotocin in mice”, Mycoscience, vol. 41, 2000, pp. 473-480.
Keiko Kubo and Hitoaki Nanba. “Anti-Diabetic Mechanism of Maitake (Grifola frondose)”, Penn. State Univ., 1996, pp. 215-221.
Manohar V., Talpur N.A., Echard B.W. Lieberman S. and Preuss H.G. “Effects of a water-soluble extract of maitake mushroom on circulating glucose/insulin concentrations in KK mice”, Diabetes, Obesity and Metabolism, vol. 4, 2002, pp. 43-48.
Talpur N.A., Echard B.W., Fan A.Y., Jaffari O., Bagchi D. and Preuss H.G. “Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains”, Molecular and Cellular Biochemistry, vol. 237, 2002, pp. 129-136.

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