Glycoprotein VI and uses thereof

Details Glycoprotein VI and uses thereof Glycoprotein VI and uses thereof

2006-09-05

2006-09-05

Chan, Christina (Department: 1644)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C424S135100, C436S512000, C436S545000, C436S546000, C530S387100, C530S387300, C530S388200, C530S388700

Reexamination Certificate

active

07101549

ABSTRACT:
The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

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