Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-07
1999-03-09
Tsang, Cecilla J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 54, 530395, 530396, 536 551, 536 552, 5361231, 436503, 4241431, A61K 3815, C07H 504
Patent
active
058800913
ABSTRACT:
P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by H!glucosamine-labeled HL-60 cell extracts on immobilized P-selectin. This molecule was characterized and distinguished from other well-characterized neutrophil membrane proteins with similar apparent molecular mass. The purified ligand, or fragments thereof (including both the carbohydrate and protein components), or antibodies to the ligand, or fragments thereof, can be used as inhibitors of binding of P-selectin to cells.
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Joh
Cummings Richard D.
McEver Rodger P.
Moore Kevin L.
Mohamed Abdel A.
The Board of Regents of the University of Oklahoma
Tsang Cecilla J.
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