Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1996-11-13
1998-12-29
Knode, Marian C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
4241861, 4242041, 4242301, 4242311, 4353201, 536 2372, 530350, 530300, A61K 3412, C12N 1500
Patent
active
058537341
ABSTRACT:
This invention provides an isolated nucleic acid molecule which encodes KSHV glycoprotein L (gL). This invention provides an isolated nucleic acid molecule which encodes KSHV glycoprotein M (gM). This invention provides isolated gL and gM polypeptides. This invention provides antibodies specific to the polypeptides. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a vaccine for Kaposi's Sarcoma (KS). This invention provides methods of vaccination, prophylaxis, diagnosis and treatment of a subject with KS and of detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.
REFERENCES:
Chang et al, 1994, Scinece, vol. 266, pp. 1865-1869.
Boshoff et al, 1995, Lancet, vol. 345, pp. 1043-1044.
Casarman et al, 1995, Blood, vol. 86, (7), pp. 2708-2714.
Bohenzky Roy A.
Chang Yuan
Edelman Isidore S.
Moore Patrick S.
Russo James J.
Knode Marian C.
Salimi Ali R.
The Trustees of Columbia University in the City of New York
White John P.
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