Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Plant proteins – e.g. – derived from legumes – algae or...
Patent
1988-04-28
1994-08-02
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Plant proteins, e.g., derived from legumes, algae or...
530395, 530423, 530823, A61K 3702, C07K 302, C07K 1510, C07K 1514
Patent
active
053347048
ABSTRACT:
Disclosed herein is a novel glycoprotein derived from Ganoderma mycelia. The glycoprotein is free of human hemagglutination ability, and has immunosuppressive activities and a molecular weight of 16,000-18,000 as measured by SDS gel electrophoresis or 12,000-16,000 as measured by tricin-SDS gel electrophoresis. The glycoprotein is produced by culturing Ganoderma mycelia, extracting the resultant Ganoderma mycelia with an aqueous solvent, and then purifying the resultant extract. An immunosuppressive agent containing an effective amount of the glycoprotein is also disclosed.
REFERENCES:
Biosis Abstract, Tseng et al., Bot. Bull. Acad. Sinica, vol. 29 (3) pp. 189-200, 1988.
WPI Abstract, JP 60-056924 A published Apr. 2, 1985.
WPI Abstract, JP 57.gtoreq.075926 A publ. May 12, 1982.
Chem. Abst., vol. 104 No. 16, entry #135927u (1985).
Chem. Abstr., vol. 77 (6) entry #44311j (1980).
Chem. Abstr., vol. 95 (11) entry #93841z (1980).
Kim et al., Kor. J. Mycol., vol. 8 No. 2 pp. 107-113 (1980).
Mizuno et al., Nippon Nogeik. Kaishi, vol. 59 No. 11 pp. 1143-1151 (1985).
Tseng et al., Bot. Bull. Academia Simica vol. 29 No. 3 pp. 189-199 (1988).
Teikoku Chem. Ind Ltd, J5 7075-926, abstract in English.
Kino Kousuke
Tsunoo Hajime
Yamashita Akio
Meiji Milk Products Co. Ltd.
Russel Jeffrey E.
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