Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1989-07-07
1993-01-12
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530827, C07K 1514
Patent
active
051791986
ABSTRACT:
The present invention provides a glycoprotein derived from human cell membrane, which has a molecular weight of 20 to 25 Kd as estimated by SDS polyacrylamide gel electrophoresis, and contains N-glycoside type carbohydrate chain and phosphatidylinositol, and possesses an inhibitory activity to complement-mediated cell membrane damage. The present invention further provides a gene coding for the glycoprotein, and a method for the production of the glycoprotein and the gene therefor.
REFERENCES:
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Okada et al. 1989. Biochem. Biophys. Res. Commun. 162(3): 1553-1559.
Y. Sugita et al., J. Biochem. 104, 633-637 (1988).
I. Stefanova, et al., Mol. Immunol. 26, 153-161 (1989).
N. Okada et al., International Immunol. 1, 205-208 (1989).
M. H. Holguin et al., J. Clin. Invest. 84, 7-17 (1989).
H. Okada et al., Biochem. Biophys. Res. Comm. 162, 1553-1559 (1989).
Kondo Jun
Nagami Yoichi
Okada Hidechika
Okada Noriko
Takahashi Kazuhiro
Conlin David G.
Draper Garnette D.
Furman Keith C.
Mitsubishi Corporation
Okada Hidechika
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