Glycophospholipid

Details Glycophospholipid Glycophospholipid

1995-05-15

1999-01-05

Peselev, Elli

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 172, 536 179, C07H 1300

Patent

active

058564535

ABSTRACT:
The present invention relates to glycophospholipids represented by the ##STR1## The glycophospholipid of the present invention can be obtained by extracting lipid fraction of whey, butter milk, etc. with a mixed solvent of chloroform/methanol and purifying by silica gel chromatography.
The glycophospholipid of the present invention is that having a novel structure and existing in milk lipid, and utilized as a biochemical reagent, a starting material for medicine and foodstuff or a surfactant.

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patent: 4957768 (1990-09-01), Dutilh
patent: 5183680 (1993-02-01), Jodlbauer
J.D. Billimoria et al., "Synthesis of Phosphatidylethanolamine-N-Glucoside" Chemistry and Industry 1731-1732 (1968).
J.D. Billimoria et al., "The Phospholipids of Butter and Their Effect on Blood Coagulation" Biochemical Journal 78(1):185-194 (1961).
T. Mizuochi et al., "A Library of Oligosaccharide Probes (Neoglycolipids) from N-Glycosylated Proteins Reveals That Conglutinin Binds to Certain Complex-Type as Well as High Mannose-Type Oligosaccharide Chains" Journal of Biological Chemistry 264(23:13834-13839 (1989).
Y.S. Park et al., "Interaction of Synthetic Glycophospholipids with Phospholipid Bilayer Membranes" Biochimica et Biophysica Acta 1112:251-258 (1992).
Y.S. Park et al., "Cryoprotective Activity of Synthetic Glycophospholipids and Their Interactions with Trehalose" Biochimica et Biophysica Acta 1124:241-248 (1992).
C.A.A. Van Boeckel et al., "Phosphotriester Approach To The Synthesis of .alpha.-Glucosylated Mono- and Diphosphatidyl Glycerols: Bacterial Cell-Wall Components", Tetrahedron, vol. 37, No. 21, pp. 3751-3761 (1981).
J.J. Oltvoort et al., "A simple approach to the synthesis of a membrane teichoic acid fragment of Staphylococcus aureus", Recueil, Journal of the Royal Netherlands Chemical Society, 101/3, pp. 87-91 (1982).
C.A.A. Van Boeckel and J.H. Van Boom, "Synthesis of Glucosylphosphatidylglycerol Via A Phosphotriester Intermediate", Tetrahedron Letters, No. 37, pp. 3561-3564, (1979).
C.A.A. Van Boeckel and J.H. Van Boom, "Synthesis Of Phosphatidyl-.alpha.-Glucosyl-Diacylglycerol Containing Palmitic And Oleic Acid Esters", Tetrahedron Letters, No. 21, pp. 3705-3708, (1980).

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