Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides containing saccharide radicals – e.g. – bleomycins – etc.
Reexamination Certificate
2003-03-27
2008-10-21
Jiang, Shaojia Anna (Department: 1623)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Peptides containing saccharide radicals, e.g., bleomycins, etc.
C514S008100, C536S004100
Reexamination Certificate
active
07439322
ABSTRACT:
The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme ofAmycolatopsis orientalis.Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.
REFERENCES:
patent: 6232102 (2001-05-01), Baltz et al.
Zmijewski et al., Glycopeptide Antibiotics, Genetic and Biochemistry of Antibiotic Production Ed. L.C. Vining and Stuttard, Butterworth Heinemann, Boston, pp. 71-83, 1995.
Chung, S. et al. “Biosynthetic Studies of Aridicin Antibiotics: Microbial Transformations and Glycosylations by Protoplasts.”Journal of Antibiotics, vol. 39, No. 5, pp. 652-659 (May 1986).
Zmijewski, Jr., M. et al., “Biosynthesis of vancomycin: identification of TDP-glucose: aglycosyl-vancomycin glucosyltransferase fromAmycolatopsis orientalis,” FEMS Microbiology Letters, vol. 5, pp. 129-134 (1989).
Zmijewski, Jr., M. et al., “Chapter 18: Glycopeptide Antibiotics,”Genetic and Biochemistry of Antibiotic Production Ed.L.C. Vining and C. Stuttard. Butterworth Heineman, Boston. pp. 71-83 (1995).
Baltz Richard H.
Solenberg Patricia J.
Treadway Patti J.
Eli Lilly and Company
Jiang Shaojia Anna
McIntosh, III Traviss C
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