Glycopeptide remodeling using amidases

Details Glycopeptide remodeling using amidases Glycopeptide remodeling using amidases

2008-05-06

2008-05-06

Saidha, Tekchand (Department: 1652)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Transferases

C435S015000, C435S193000, C435S252300

Reexamination Certificate

active

10497283

ABSTRACT:
This invention provides methods for modifying glycosylation patterns of glycopeptides, including recombinantly produced glycopeptides. Also provided are glycopeptide compositions in which the glycopeptides have a homogeneous glycosylation pattern.

REFERENCES:
patent: 2002/0150981 (2002-10-01), Canfield
Kuhn et al. JBC 270(49): 29493-97, Dec. 1995.
PNGase-F amidase sequence from F. meningosepticum (Registry Nos. 128688-70-0).
PNGase-F amidase from F. meningosepticum (Registry Nos. 128688-71-1).
Hayes et al. The Biosynthesis of Oligosaccharides in Intact Golgi Preparations From Rat Liver. Analysis of N-linked and O-Linked Glycans Labeled by UDP-[6-3H]N-Acetylgalactosamine. Journal Biol. Chem. Aug. 5, 1993 vol. 268, No. 22, pp. 16170-16178.

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