Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Separation or purification
Patent
1987-02-27
1989-07-04
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Separation or purification
530322, 530317, 435 71, C07K 312
Patent
active
048451940
ABSTRACT:
An improvement in the large-scale recovery of vancomycin-type glycopeptide antibiotics which comprises (1) commingling the fermentation medium in which the antibiotic is produced with a polystyrene divinylbenzene resin such as Dow XFS-43278.00, (2) separating the resin from the medium and (3) eluting the antibiotic from the resin. This improvement avoids preliminary filtration and pH adjustment of the broth, simplifies waste-disposal problems and eliminates antibiotic losses due to mycelial adsorption and filtration.
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Glass Suzanne L. E.
Johnson Charles W.
Spencer John L.
Eli Lilly and Company
Harrison Nancy J.
Phillips Delbert R.
Wessendorf T. D.
Whitaker Leroy
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