Glycopeptide derivatives

Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis

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2601125R, 514 8, A01N 2500, C07C10352, A61K 3700

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active

045044678

ABSTRACT:
Method of preparing compounds of formula 1: ##STR1## by oxidative deamination of a glycopeptide antibiotic of formula 2: ##STR2## the antibiotic being selected from A35512 factors A, B, C, E and H, A35512B pseudoaglycone, actaplanin factors A, B.sub.1, B.sub.2, B.sub.3, C.sub.1a, C.sub.2a, C.sub.3, D.sub.1, D.sub.2, E.sub.1, G, K, L, M, N and O, actaplanin pseudoaglycone, A41030 factors A, B, C, D, E, F and G, A47934, ristocetin A and ristocetin A pseudoaglycone, novel compounds and compositions and methods of increasing feed-utilization efficiency in animals are provided.

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R. B. Kelly, "Phenylhydrazide as a Protective Group in Peptide Synthesis. The Oxidation of .gamma.-Phenylhydrazides of N-Carbobenzoxy.gamma.-L-Glutamylamino Acid Esters with Manganese Dioxide," J. Org. Chem. 28, 453-456 (1963).
R. B. Kelly et al., "The Oxidation of Phenylhydrazides to Carboxylic Acids with Manganese Dioxide. II. By Products," J. Org. Chem. 29, 1273-1275 (1964).
H. B. Henbest and A. Thomas, "Amine Oxidation. Part I. The Side Chain Oxidation of N-Alkyl- and NN-Dialkyl-Anilines by Manganese Dioxide," J. Chem. Soc. 3032-3039 (1957).
D. H. Williams et al., "Structure of Ristocetin A," J. C. S. Chem. Com. 1979, 906-908.

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