Glycopeptide antibiotics and process of preparation

Details Glycopeptide antibiotics and process of preparation Glycopeptide antibiotics and process of preparation

1984-04-16

1985-11-12

Brown, Johnnie R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

536 71, 536 168, 536 181, C07C10352, C07H 1520

Patent

active

045527016

ABSTRACT:
Desvancosaminyl- and des(vancosaminyl-O-glucosyl) glycopeptides, and methods for their preparation by treating a glycopeptide selected from vancomycin, A51568A, A51568B, M43A and M43D with trifluoroacetic acid under controlled conditions, are provided. The new glycopeptides are useful antibacterial agents.

REFERENCES:
patent: 3067099 (1962-12-01), McCormick et al.
patent: 4196280 (1980-04-01), Umezawa et al.
patent: 4299953 (1981-11-01), Hamill et al.
Donald J. McGraw, "The Antibiotic Discovery Era (1940-1960): Vancomycin as an Example of the Era," Thesis at Oregon State University, 1975, pp. 78-142.
F. J. Marshall, "Structure Studies on Vancomycin," J. Med. Chem. 8, 18-22, (1965).
G. M. Sheldrick et al., "Structure of Vancomycin and its Complex with Acetyl-D-alanyl-D-alanine," Nature 271, 223-225, (1978).
C. M. Harris et al., "Structure of the Glucopeptide Antibiotic Vancomycin, Evidence for an Asparagine Residue in the Peptide," J. Am. Chem. Soc., 104, pp. 4293-4295.
"Vancomycin and Factor A," Report by Eli Lilly and Company sent to the U.S. Food and Drug Administration on Mar. 5, 1963.
G. K. Best et al., "Chromatographic Separation of the Vancomycin Complex," Antimicrob. Agents & Chemotherapy-1968, 115-119.
R. R. Pfeiffer, "Structural Features of Vancomycin," in Reviews of Infectious Diseases, vol. 3 Supplement (1981).

Affiliated with

Also associated with

Rating

Glycopeptide antibiotics and process of preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Glycopeptide antibiotics and process of preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glycopeptide antibiotics and process of preparation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1878881