Glycopeptide antibacterial compounds, compositions...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C514S001000, C514S008100, C514S023000

Reexamination Certificate

active

06841661

ABSTRACT:
The present invention relates to vancomycin analogs in which the vancosamine residue is substituted with a lipid-like substituent that includes a first aryl moiety and a second aryl moiety joined together by a flexible linker moiety, that is not a single bond directly joining the first aryl moiety and the second aryl moiety, and a glucose C-6 substituent modified to be other than the naturally occurring hydroxyl group, or pharmaceutically acceptable salts thereof.

REFERENCES:
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patent: 0802199 (1997-10-01), None
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patent: WO 0004044 (2000-01-01), None
patent: WO 0042067 (2000-07-01), None
PCT Notification of Transmittal of The International Search Report or the Declaration dated Oct. 10, 2000.
“In Vivo Activity and Pharmacokinetic Evaluation of a Novel Long-Acting Carbaapenem Antibiotic, MK-826 (L-749,345)”, Charles J. Gill et al, Antimicrobial Agents and Chemotherapy, Aug. 1998, vol. 42, No. 8, pp. 1996-2001.
“The Use of the Angular Transformation in Biological Assays*”, Lila F. Knudsen et al, American Statistical Association, pp. 282-296.
“Antibacterial Activities and Modes of Actiioon of Vancomycin and Related Glycopeptides”, R. Nagarajan, Antimicrobial Agents and Chemotherapy, Apr. 1991, pp. 605-609.
“Selective Cleavage of Vancosamine, Glucose, and N-Methyl-leucine from Vancomycin and Related Antibiotics”, R. Nagaarajan et al, J. Chem. Soc., Chem. Commun., 1988, pp. 1306-1307.
“Structural Modifications of Glycopeptide Antibiotics”, Adriano Malabarba et al, Medical Research Reviews, 1997, vol. 17, No. 1, pp. 69-137.
“Synthesis and Biological Activity of Derivatives of Glycopeptide Antibiotics Eremomycin and Vancomycin Nitrosated, Acylated or Carbamoyloated at the N-Terminal”, A. Y. Pavlov et al, Journal of Antibiotics, Nov. 1993, vol. 46, No. 11, pp. 1731-1739.

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