Glycopeptide and oligosaccharide antibacterial compositions

Details Glycopeptide and oligosaccharide antibacterial compositions Glycopeptide and oligosaccharide antibacterial compositions

1985-10-09

1990-07-03

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 23, 514 24, 514 25, 514 27, 514 54, 514 61, 530350, 530370, 530376, 530396, 530402, 530395, A61K 3578, A61K 3173, A61K 4742, A61K 4748

Patent

active

049391232

ABSTRACT:
Adherence of pathogenic bacteria having type I fimbriae to animal cells is inhibited by compositions having active constituents which are new glycopeptide and/or oligosaccharide compounds. The active constituent compounds are prepared enzymatically from vegetable flour which contains reserve glycoproteins rich in oligomannosides, preferably from a fraction enriched with soya glycoprotein 7S or with bean glycoprotein II, although glycopeptides from ovalbumin may be utilized for the preparation of the compounds. The compounds have a polymannosidic basic structure similar to that of epithelial cells which is recognized by various pathogenic bacteria and which results in neutralizing the bacteria so they do not adhere to the cells. Compositions including the active constituent compounds are effective for use in the prophylaxis, treatment and diagnosis of infectious diseases, especially those caused by coliform bacteria, and also for use in the disinfection of surfaces.

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