Glycopegylated erythropoietin formulations

Details Glycopegylated erythropoietin formulations Glycopegylated erythropoietin formulations

2006-05-25

2010-11-30

Ha, Julie (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S008100, C514S012200, C530S303000, C530S324000, C530S351000, C530S388230

Reexamination Certificate

active

07842661

ABSTRACT:
The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

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