Glycolytic promoters for regulated protein expression: protease

Details Glycolytic promoters for regulated protein expression: protease Glycolytic promoters for regulated protein expression: protease

1992-06-08

1993-06-08

Low, Christopher S. F.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

4351723, 4353201, 435 691, 435256, 435254, 435255, 930250, 935 11, 530380, C07K 1300

Patent

active

052180913

ABSTRACT:
Promoters associated with expression of specific enzymes in the glycolytic pathway are used for expression of alien DNA, particularly yeast promoters known to provide high enzyme levels of enzymes in the glycolytic pathway are employed for expressing a mammalian protein, such as .alpha..sub.1 -antitrypsin. The promoters include promoters involved in expression of pyruvate kinase, triose phosphate isomerase, phosphoglucose isomerase, phosphoglycerate mutase, hexokinase 1, hexokinase 2, glucokinase, phosphofructokinase, and aldolase, as well as the glycolytic regulation gene. Particularly, the glycolytic regulation gene can be used in conjunction with promoters in the glycolytic pathway for regulated production of desired proteins.

REFERENCES:
patent: 4732973 (1988-03-01), Barr
Leicht et al., Nature vol. 297 pp. 655-659 Jun. 24, 1982.
Lawn et al., Cell vol. 15 pp. 1157-1174 (1978).
Maniatis et al., Cell vol. 15 pp. 687-701 Oct. 1978.
Tacon et al., Molec. Gen. Genet vol. 177, pp. 427-438 (1980).
Goeddel et al, Nature vol. 287 Oct. 2, 1980.
Bagdasarian et al., J. Clin. Invest. vol. 67, pp. 281-291 Jan. 1981.
Pannell et al., Biochemistry vol. 13 5439-5445 1974.
Kurachi et al., PNAS USA vol. 78 6826-6830 Nov. 1981.
Cannell et al., Biochem. Biophys Res. Comm. vol. 91, pp. 1032-1037 Dec. 1979.
Berman et al., Trends in Biotechnology vol. 3 No. 2 pp. 51-53 (1985).
Cabezon, et al. 1984 Proc. Natl. Acad. Sci. 81, 6594-6598.
Marglin et al. 1970, Ann. Rev. Biochem. 39, 841-866.
van der Straten et al. 1986, DNA 5, 129-136.
Bollen et al. 1983, DNA 2, 255-264.
Chandra et al. 1981, Biochem. Biophys. Res. Commun. 103, 751-758.
Owen, et al., Biochim. Biophys. Acta 453: 257-261 (1976).
Weiland, et al. Blut 44: 173-175 (1982).
Olden, et al., J. Cell, Biochem. 18: 313-335 (1982).
Bazill, et al., Biochem. J. 210: 747-759 (1983).
Dahl, et al., Science 239: 72-74 (1988).
Sairam and Bhargavi, Science 229: 65-67 (1985).
Hoffman, et al., J. Clin. Invest. 75: 1174-1182 (1985).
Sharon and Lis, Chem. Eng. News 59 (13): 21 (1981).
Karp, et al., J. Biol. Chem. 257: 7330-7335 (1982).

Affiliated with

Also associated with

Rating

Glycolytic promoters for regulated protein expression: protease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Glycolytic promoters for regulated protein expression: protease , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glycolytic promoters for regulated protein expression: protease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1935049