Glycoluril core molecules for combinatorial libraries

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C548S302700, C548S303100, C435S091500, C435S091500

Reexamination Certificate

active

07126006

ABSTRACT:
The present invention provides novel glycoluril derivatives for use as core molecules in combinatorial chemistry. Core molecules of the present invention can contain from one to six building blocks. Preferred building blocks are substituted amine radicals. Combinatorial libraries containing such core molecules are also provided.

REFERENCES:
patent: 3071591 (1963-01-01), Patterson
patent: WO 95/19359 (1995-11-01), None
Reek et al., J. Am. Chem. Soc. 1997, vol. 119, pp. 9956-9964.
Ugi, et al., “Multicomponent Reactions in Organic Chemistry”,Endeavor 18: 115-122 (1994).
Carell, et al., “A Novel Procedure for the Synthesis of Libraries Containing Small Organic Molecules”,Angew. Chem. Int. Ed. Engl. 33: 2059-2061 (1994).
Carell, et al., “A Solution-Phase Screening Procedure for the Isolation of Active Compounds from a Library of Molecules”,Angew. Chem. Int. Ed. Engl. 33: 2061-2064 (1994).
Smith, et al., “Synthesis and Biological Evaluation of a Library Containing Potentially 1600 Amides/Esters. A Strategy for Rapid Compound Generation and Screening”,Bioorg. Med. Chem. Lett. 4: 2821-2824 (1994).
Pirrung, et al., “Preparation and Screening Against Acetylcholinesterase of a Non-Peptide “Indexed” Combinatorial Library”,J. Am. Chem. Soc. 117: 1240-1245 (1995).
Carell, et al., “New Promise in Combinatorial Chemistry: Synthesis, Characterization, and Screening of Small-Molecule Libraries in Solution”,Chem. Biol. 2: 171-183 (1995).
Pirrung, et al., “Discovery of a Novel Tetrahydroacridine Acetylcholinesterase Inhibitor Through an Indexed Combinatorial Library”,Chem. Biol. 2: 621-626 (1995).
Han, et al., “Liquid-Phase Combinatorial Synthesis”,Proc. Natl. Acad. Sci. USA 92: 6419-6423 (1995).
Dunayevskiy, et al., “Characterization of the Complexity of Small-Molecule Libraries by Electrospray Ionization Mass Spectrometry”,Anal. Chem. 67: 2906-2915 (1995).
Früchtel, et al., “Organic Chemistry on Solid Supports”,Angew. Chem. Int. Ed. Engl. 35: 17-42 (1996).
Armstrong, et al., “Multiple-Component Condensation Strategies for Combinatorial Library Synthesis”,Acc. Chem. Res. 29: 123-131 (1996).
Boger, et al., “Generalized Dipeptidomimetic Template: Solution Phase Parallel Synthesis of Combinatorial Libraries”,J. Am. Chem. Soc. 118: 2109-2110 (1996).
Cheng, et al., “Novel Solution Phase Strategy for the Synthesis of Chemical Libraries Containing Small Organic Molecules”,J. Am. Chem. Soc. 118: 2567-2573 (1996).
Keating, et al., “Postcondensation Modifications of Ugi Four-Component Condensation Products: 1-Isocyanocyclohexene as a Convertible Isocyanide. Mechanism of Conversion, Synthesis of Diverse Structures, and Demonstration of Resin Capture”,J. Am. Chem. Soc. 118: 2574-2583 (1996).
Hermkens, et al., “Solid-Phase Organic Reactions: A Review of the Recent Literature”,Tetrahedron 52: 4527-4554 (1996).
Wrighton, et al., “Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin”,Science 273: 458-463 (1996).
Livnah, et al., “Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8Å”,Science 273: 464-471 (1996).
Shipps, et al., “Solution-Phase Generation of Tetraurea Libraries”,Bioorg. Med. Chem. 4: 655-657 (1996).
Cheng, et al., “A Solution-Phase Strategy for the Synthesis of Chemical Libraries Containing Small Organic Molecules: A Universal and Dipeptide Mimetic Template”,Bioorg. Med. Chem. 4: 727-737 (1996).
Thompson, et al., “Synthesis and Applications of Small Molecule Libraries”,Chem. Rev. 96: 555-600 (1996).
Pryor, et al., “The Activated Core Approach to Combinatorial Chemistry: A Selection of New Core Molecules”,Tetrahedron 54: 4107-4124 (1998).
Smeets, et al., “Synthesis and Binding Properties of Basker-Shaped Hosts”,J. Org. Chem 54: 3710-3717 (1989).
Rudkevich, et al., “Chemical Selection and Self-Assembly in a Cyclization Reaction”,Angew. Chem. Int. Ed. Engl. 36: 846-848 (1997).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Glycoluril core molecules for combinatorial libraries does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Glycoluril core molecules for combinatorial libraries, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glycoluril core molecules for combinatorial libraries will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3711919

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.