Glycolipids

Details Glycolipids Glycolipids

1988-09-09

1990-12-11

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Azides

548225, 424 858, 514 8, C07C11700, C07F 718, C07F11706

Patent

active

049772864

ABSTRACT:
Novel, optically active azido alcohols are synthesized from N-haloacetyl oxazolidinone and are coupled with protected, activated carbohydrate residues in stereoselective glycosidic fashion to provide glycolipids in substantially pure stereochemical form. In accordance with certain preferred embodiments, the glycosphingolipids globotriaosylceramide, lactosyl ceramide, and galactosyl ceramide are synthesized in substantially pure stereochemical form from alkenyl, C-18 azido alcohols and protected fluoroglycosides and are employed as antigens in the production of antibodies useful, for example, in the treatment of disease.

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