Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1996-10-23
1998-01-06
Prouty, Rebecca E.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
424 943, 435188, 435209, A61K 3847, C12N 996, C12N 942
Patent
active
057051534
ABSTRACT:
Conjugates containing glucocerebrosidase and non-antigenic polymers such as polyethylene glycol are disclosed. The conjugates circulate for extended times and have prolonged activity in vivo when compared to unmodified enzymes. The conjugates are useful in the treatment of Gaucher's Disease and have improved enzyme activity at the pH ranges associated with lysosomal, arterial and capillary regions.
REFERENCES:
patent: 3910822 (1975-10-01), Pentcher
patent: 4179337 (1979-12-01), Davis et al.
patent: 4749570 (1988-06-01), Poznansky
patent: 4935465 (1990-06-01), Garman
patent: 5122614 (1992-06-01), Zalipsky
Drugs 44(1):72-93 1992.
Nucci, et al. Advanced Drug Delivery Reviews, 6 (1991) 133-151.
Barton, et al. New England Journal of Medicine vol. 324 No. 21, pp. 1464-1470 (May 1991).
New England Journal of Medicine vol. 328 No. 21 pp. 1566-1567; Letters to the Editor (May 1993).
Dawson, et al. The Journal of Biological Chemistry vol. 245 No. 2 Issue of Jan. 25, 1970 pp. 410-416.
Herschfeld, et al. New England Journal of Medicine vol. 316 No. 10 pp. 589-596 (Mar. 1987).
Herschhom, R. New England Journal of Medicine vol. 316 No. 10 pp. 623-624 (Mar. 1987).
Enzyme Replacement In Genetic Diseases, Grabowski, et al. pp. 167-208 of Enzymes as Drugs Edited by John S. Holcenberg and Joseph Roberts, 1981 John Wiley & Sons, Inc.
Cho Myung-Ok
Gilbert Carl W.
Ginns Edward J.
Martin Brian M.
Shorr Robert G. L.
Prouty Rebecca E.
The United States of America, as represented by The Department o
LandOfFree
Glycolipid enzyme-polymer conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Glycolipid enzyme-polymer conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glycolipid enzyme-polymer conjugates will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2326470