Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Stablizing an enzyme by forming a mixture – an adduct or a...
Patent
1994-11-30
1997-04-15
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Stablizing an enzyme by forming a mixture, an adduct or a...
435209, 424 9461, 424 943, C12N 996, C12N 942, A61K 3847
Patent
active
056208847
ABSTRACT:
Conjugates containing glucocerebrosidase and non-antigenic polymers such as polyethylene glycol are disclosed. The conjugates circulate for extended times and have prolonged activity in vivo when compared to unmodified enzymes. The conjugates are useful in the treatment of Gaucher's Disease and have improved enzyme activity at the pH ranges associated with lysosomal, arterial and capillary regions.
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Cho Myung-Ok
Gilbert Carl W.
Ginns Edward J.
Martin Brian M.
Shorr Robert G. L.
Enzon Inc.
Mercanti Michael N.
Prouty Rebecca
Wax Robert A.
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