Glycolipid derivatives acting as ligands for selectins

Details Glycolipid derivatives acting as ligands for selectins Glycolipid derivatives acting as ligands for selectins

1995-03-01

1996-12-31

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 61, 536 41, 536 172, 536 184, 536118, 536119, 536122, A61K 3170, C07H 306, C07H 1100, C07H 1504

Patent

active

055894658

ABSTRACT:
Novel glycolipid derivatives of Formula (I): ##STR1## wherein R is a long chain alkyl, or their salts are disclosed. These compounds act as a ligand for selectin family and exhibit a remarkable inhibitory effect on the binding of selectin family to its native ligand sialyl Lewis.sup.x.

REFERENCES:
patent: 5440015 (1995-08-01), Macher et al.
patent: 5444050 (1993-08-01), Kogan et al.
patent: 5460945 (1995-10-01), Springer et al.
Hasegawa et al. J. Carbohydrate Chem. 1993, 12(8), 1203-1216.

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