Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1993-07-15
1994-11-29
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 54, 536 174, A61K 3172
Patent
active
053690966
ABSTRACT:
Disclosed are glycolipid derivatives of formula (I) ##STR1## wherein X is a group selected from ##STR2## n is 0 or an integer of 1-10 and R denotes a branched hydrocarbon chain containing from 19 to 39 carbon atoms. Those compounds are useful as antiinflammatory agents, or as agents for the treatment of rheumatoid arthritis.
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Akihiko Kameyama, et al., Synthetic Studies on Sialoglycoconjugates 22: Total Synthesis of Tumor-Associated Ganglioside, Sialyl Lewis X1, Journal of Carbohydrate Chemistry, 10 pp. 549-560 1991.
Fumito Yamazaki, et al., Synthesis of alpha-D-MANp-(1->3)-[beta-D-GlcpNAc-(1->4)]-[alpha-D-MANp-(1->6)]-beta-D-M ANp-(1->4)-beta-D-GlcpNAc-(1->4)-[alpha-L-Fucp-(1->6)]-D-GlcpNAc, A Core Glycoheptaose of a "Bisected" Complex-Type Glycan of Glycoproteins Carbohydrate Research, 201. pp. 31-50. Jul. 17, 1989.
Takatoshi Murase, et al., A Facile, Regio- and Stereo-Selective Synthesis of Ganglioside GM Carbohydrate Research 188 pp. 71-80 1989.
Akiko Takada, et al. Contribution of Carbohydrate Antigens Sialyl Lewis A and Silyl Lewis X to Adhesion of Human Cancer Cells to Vscular Endo Thelium Cancer Research 53: pp. 354-361 Jan. 15, 1993.
Proc. Natl. Acad. Sci. USA, vol. 88, Nov. 1991, pp. 10372-10376, David Tyrrell, et al., "Structural Requirements for the Carbohydrate Ligand of E-Selectin".
Adachi Keisuke
Kameyama Akihiko
Takahashi Naofumi
Yamada Yutaka
Fonda Kathleen Kahler
Rollins John W.
The Nisshin Oil Mills Ltd.
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