Glycolipid containing N-glycolylneuraminic acid and method of pr

Details Glycolipid containing N-glycolylneuraminic acid and method of pr Glycolipid containing N-glycolylneuraminic acid and method of pr

1987-10-19

1990-08-21

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 53, 536 551, 536 552, 536 553, 536124, 536121, 536 172, C07H 500, C07H 100, C07H 1100

Patent

active

049507508

ABSTRACT:
The present invention provides ganglioside-related compounds expressed by the following formula: ##STR1## (wherein R.sub.1 denotes a hydrogen atom or SiR.sub.3 R.sub.4 R.sub.5 (wherein R.sub.3 and R.sub.4 each denotes a methyl or phenyl group, and R.sub.5 denotes a tertiary butyl or dimethylphenylmethyl group), and R.sub.2 denotes a hydrogen atom, a trityl group, or ##STR2## (wherein M denotes an alkali metal atom)) and methods of producing the same. These ganglioside-related compounds are useful as markers for the early detection of cancer and in the immunotherapy for cancer.

REFERENCES:
patent: 4774326 (1988-09-01), Shibayama et al.
Sugimoto et al., Glycoconjugate J (1985) 2:5-9.

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