Glycolipid analogs

Details Glycolipid analogs Glycolipid analogs

1995-05-31

1999-01-19

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554 51, 554 55, 554 61, 554 65, 514613, 514625, C07C23300

Patent

active

058615202

ABSTRACT:
The present invention provides a compound which is a glycolipid analog having a novel structure represented by the formula (1): ##STR1## wherein Z represents an imino group, an oxygen atom or a sulfur atom; m is an integer of from 3 to 12; and n is an integer of from 4 to 22; and shows a potent activity of inhibiting glycosidase and has potential physiological activities, for example, antiviral activity. The invention also provides a glycosidase inhibitor which comprises said glycolipid analog as an active ingredient.

REFERENCES:
patent: 5095119 (1992-03-01), Ocain et al.
Ogawa et al., "Synthesis of Glucosylceramide Analogues", J. Chem. Soc., Chem. Commun., vol. 11, Jun. 1994, pp. 1317-1318.
Tsonado et al., "Synthesis of Glycosylceramide Analogs Composed of Imino-Linked Unsaturated 5a-Carbaglycosyl Residues", Liebigs Annalen, vol. 2, 1 Feb. 1995, pp. 279-284.
Ogawa et al., "Chemical Modification of the Sugar Moiety of Methyl Acarviosin", Carbohydrate Research, vol. 250, 1993, pp. 177-184.
Osieki-Newman et al, "Human acid .beta.-glucosidase", Biochimica et Biophysica Acta, vol. 915, 1987 pp. 87-100.
Greenberg et al., "Human Acid .beta.-glucoisidase", Biochimica et Biophysica Acta, vol. 1039, 1990 pp. 12-20.

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