Glycolic acid platinum complexes

Details Glycolic acid platinum complexes Glycolic acid platinum complexes

1983-11-17

1985-12-24

Sneed, Helen M. S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

514492, C07F 1500

Patent

active

045607818

ABSTRACT:
Novel water-soluble glycolic acid platinum complexes which have more potent antitumor activity with lower nephrotoxicity than cisplatin are provided.
They can be administered parenterally to mice attacked by malignant tumors.
Prepared from dinitrato-platinum complexes of amines on treatment with anion exchange resins and subsequent reaction with glycolic acid.

REFERENCES:
patent: 4225529 (1980-09-01), Hydes et al.
patent: 4230631 (1980-10-01), Hydes et al.
patent: 4250189 (1981-02-01), Hydes et al.
patent: 4271085 (1981-06-01), Amundsen et al.
patent: 4359425 (1982-11-01), Totani et al.
patent: 4466924 (1984-08-01), Verbeek et al.
Chemical Abstracts, 92, 88521d; 92, 51723v, (1980).
Chemical Abstracts, 93, 125662u, (1980); 93, 125663v, (1980).
Chemical Abstracts, 78, 105899p, (1973).
Chemical Abstracts, 80, 66593d, (1973).

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