Glycol and hydroxyphosphonate peptidomimetics as inhibitors of a

Details Glycol and hydroxyphosphonate peptidomimetics as inhibitors of a Glycol and hydroxyphosphonate peptidomimetics as inhibitors of a

1997-07-07

1999-10-05

Mach, D. Margaret M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548558, 548559, C07D20710, A61K 3140

Patent

active

059625066

ABSTRACT:
Compounds of Formula I ##STR1## are disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathepsin D. The compounds are therefore useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred compounds of Formula I, Y is an dialkoxyphosphonate, or .alpha.-hydroxyamide group and Z is an acyl or .alpha.-ketocarbamate functionality. Intermediates in the solid phase synthesis of compounds of Formula I, in which compounds are attached to a solid support, are also disclosed.

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