Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-08-30
2005-08-30
Maier, Leigh C. (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S124000, C424S194100, C424S194100
Reexamination Certificate
active
06936701
ABSTRACT:
Methods for making the functionalized glycoconjugates include (a) contacting a cell with a first monosaccharide, and (b) incubating the cell under conditions whereby the cell (i) internalizes the first monosaccharide, (ii) biochemically processes the first monosaccharide into a second saccharide, (iii) conjugates the saccharide to a carrier to form a glycoconjugate, and (iv) extracellularly expresses the glycoconjugate to form an extracellular glycoconjugate comprising a selectively reactive functional group. Methods for forming products at a cell further comprise contacting the functional group of the extracellularly expressed glycoconjugate with an agent which selectively reacts with the functional group to form a product. Subject compositions include cyto-compatible monosaccharides comprising a nitrogen or ether linked functional group selectively reactive at a cell surface and compositions and cells comprising such saccharides.
REFERENCES:
patent: 5767378 (1998-06-01), Bojsen et al.
patent: 6075134 (2000-06-01), Bertozzi et al.
Keppler, O. T. et al “Biosynthetic modulation of sialic acid-dependent virus-receptor interction of two primate polyoma viruses” Biol. Chem. (1995) vol 270, no 3, pp 1308-1314.
Bertozzi Carolyn
Mahal Lara K.
Yarema Kevin J.
Aston David J.
Maier Leigh C.
Peters Verny Jones Schmitt & Aston, LLP
The Regents of the University of California
LandOfFree
Glycoconjugates and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Glycoconjugates and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glycoconjugates and methods will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3508964