Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-05-15
2000-06-13
Celsa, Bennett
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4241931, 536 221, C07H 1500, C07H 1900, A61K 39385
Patent
active
060751347
ABSTRACT:
Methods for making the functionalized glycoconjugates include (a) contacting a cell with a first monosaccharide, and (b) incubating the cell under conditions whereby the cell (i) internalizes the first monosaccharide, (ii) biochemically processes the first monosaccharide into a second saccharide, (iii) conjugates the saccharide to a carrier to form a glycoconjugate, and (iv) extracellularly expresses the glycoconjugate to form an extracellular glycoconjugate comprising a selectively reactive functional group. Methods for forming products at a cell further comprise contacting the functional group of the extracellularly expressed glycoconjugate with an agent which selectively reacts with the functional group to form a product. Subject compositions include cyto-compatible monosaccharides comprising a nitrogen or ether linked functional group selectively reactive at a cell surface and compositions and cells comprising such saccharides.
REFERENCES:
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L. K. Mahal et al. Science, 1997, vol. 276, pp. 1125-1128.
Bertozzi Carolyn
Mahal Lara K.
Yarema Kevin J.
Celsa Bennett
Garcia Maurie
Osman Richard Aron
The Regents of the University of California
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