Glycine transporter-transfected cells and uses thereof

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

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435 71, 4352523, 4353201, 435325, 536 231, 536 235, 530350, G01N 33567

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058244867

ABSTRACT:
The present invention relates to materials and methods for the identification of agents that regulate glycine transport in or out of cells, particularly in or out of neuronal and neuronal-associated cells. Such materials include non-mammalian cells having transfected therein a glycine transporter. The methods relate to the manipulation of such cells such that agents are identified that cause intake or outflow of glycine with respect to a given glycine transporter.

REFERENCES:
Kanner and Schuldiner, CRC Critical Reviews In Biochemistry, 22, pp. 1032 et seq. (1987).
Attwell et al., Neuron, 11, pp. 401-407 (1993).
Johnson and Ascher, Nature, 325, pp. 529-531 (1987).
Fletcher et al., Glycine Transmission, (Otterson and Storm-Mathisen, eds.) pp. 193-219 (1990).
Smith et al., Neuron, 8, pp. 927-935 (1992).
Liu et al., J. Biological Chemistry, 268, pp. 22802-22808 (1993).
Jursky and Nelson, J. Neurochemistry, 64, pp. 1026-1033 (1995).
Uhl, Trends In Neuroscience, 15, pp. 265-268 (1992).
Clark and Amara, BioEssays, 15, pp. 323-332 (1993).
Yaksh, Pain, pp. 111-123 (1989).
Troung et al., Movement Disorders, 3, pp. 77-87 (1988).
Becker, FASEB J., 4, pp. 2767-2774 (1990).
Rison and Stanton, Neurosci. Biobehav. Rev., 19, pp. 533-552 (1995).
Danysz et al., Behaviorial Pharmacol., 6, pp. 455-474 (1995).
Olney and Farber, Archives General Psychiatry, 52, pp. 998-1007 (1996).
Coyle and Puttfarcken, Science, 262, pp. 689-695 (1993).
Lipton and Rosenberg, New Engl. J. of Medicine, 330, pp. 613-622 (1993).
Choi, Neuron, 1, pp. 623-634 (1988).
Pitkanen et al., Eur. J. Pharmacol., 253, pp. 125-129 (1994).
Thiels et al., Neuroscience, 46, pp. 501-509 (1992).
Kretschmer and Schmidt, J. Neurosci., 16, pp. 1561-1569 (1996).
Grimwood et al., Molecular Pharmacol., 49, pp. 923-930 (1992).
Sterner and Calligro, Soc. Neurosci. Abstr., 49, p. 351 (1995).
Calligaro et al., J. Neurochem., 60, pp. 2297-2303 (1993).
Brennan, Chem. Eng. News, pp. 41-47, (May 13, 1996).
Leeson, Drug Design For Neuroscience, (Alan P. Kozikowski, ed., 1993) pp. 339-383.
Yoneda et al., Neurochem., 62, pp. 102-112 (1994).
Yoneda et al., J. Neurochem., 60, pp. 634-645 (1993).
Palmer and Burns, J. Neurochem., 62, pp. 187-196 (1994).
Lu et al., Proc. Natl. Acad. Sci. USA, 88, pp. 6289-6292 (1991).
Kim et al. (1994) Molec. Pharm. 45: 608-617.
Blakely et al. (1988) PNAS 85: 9846-9850.
Shimada et al. (1991) Science 254:576-578.
Lipsick et al. (1986) J. Vir. 59: 267-275.

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