Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-02-13
2007-02-13
Rawlings, Stephen L. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S350000, C435S338000
Reexamination Certificate
active
10301589
ABSTRACT:
The present invention provides two unique monoclonal antibodies directed against a portion of the human Glycine N-methyltransferase, and methods of use for the monoclonal antibodies in detecting, monitoring and diagnosing malignancies characterized by down-regulation of expression or inappropriate expression of the Glycine N-methyltransferase.
REFERENCES:
patent: 1 422 527 (2004-05-01), None
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Chen et al., Genomic Structure, Expression, and Chromosomal Localization of the Human Glycine N-methyltransferase Gene, Genomics, vol. 66, No. 1, pp. 43-47, May 15, 2000.
Liu et al., Characterization of Reduced Expression of Glycine N-methyltransferase in Cancerous Hepatic Tissues Using Two Newly Developed Monoclonal Antibodies, Journal of Biomedical Science, vol. 10, No. 1, pp. 87-97, 2003.
Chen et al., Characterization of Glycine-N-Methyltransferase-Gene Experession in Human Hepatocellular Carcinoma, International Journal of Cancer, vol. 75, No. 5, pp. 787-793, Mar. 2, 1998.
Gene Research Lab. Co., Ltd.
Rawlings Stephen L.
Rosenberg , Klein & Lee
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