Glycine derivative monosodium salt tetrahydrate

Details Glycine derivative monosodium salt tetrahydrate Glycine derivative monosodium salt tetrahydrate

1994-01-18

1994-10-25

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C31115

Patent

active

053591216

ABSTRACT:
N-[o-(p-pivaloyloxybenzenesulfonylamino)benzoyl]glycine monosodium salt tetrahydrate of the formula (I): ##STR1## is non-hygroscopic, homogeneous and stable compound, and has an inhibitory effect on elastase. Accordingly, the compound may be useful for the treatment and/or prevention of diseases induced by the abnormal enhancing of degradation of elastin, collagen fiber and/or proteoglican by the action of elastase, e.g., pulmonary emphysema, atherosclerosis, rheumatoid arthritis, etc.

REFERENCES:
patent: 5017610 (1991-05-01), Imaki
Reiner Sustmann et al., Houben-Weyl, vol. E5, Georg Thieme Verlag, Stuttgart, 1985, pp. 496-504.
Hydration of Poly(ethylenimine); Chatani, Yozo Contemp. Top. Polym. Sci., 4, 531-543; 1984 Search report.

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