Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-10-02
1991-04-16
Bond, Robert T.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
549549, 540491, 560 17, 435156, C07D30613, C07D30102
Patent
active
050084119
ABSTRACT:
A process for the preparing a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, trifluoromethyl or nitro; or R.sub.1 and R.sub.2 taken together with the benzene ring to which they are attached are naphthalene, and Ar is p-lower alkoxy phenyl.
which comprises reacting ##STR2## wherein R.sub.1 and R.sub.2 are as described above with the compound of the formula ##STR3## wherein Ar is as described above, in an aromatic organic compound. The intermediates formed by the process of the invention are useful in the production of thiazepin-4(5H)-ones which have activity as calcium channel blockers and accordingly are useful as agents for lowering blood pressure and agents for treating ischemia.
REFERENCES:
patent: 3562257 (1971-02-01), Kugita et al.
patent: 4471130 (1984-11-01), Katsuki et al.
patent: 4552695 (1985-11-01), Igarashi et al.
patent: 4590188 (1986-05-01), Takeda et al.
patent: 4640930 (1987-02-01), Mohacsi et al.
patent: 4652561 (1987-03-01), Mohacsi et al.
patent: 4694002 (1987-09-01), Floyd et al.
patent: 4864058 (1989-09-01), Mohacsi
Laumen et al., J. Chem. Soc., pp. 148-150 (1989).
Whitesell et al., J. Org. Chem., vol. 50, pp. 4663-4664 (1985).
Whitesell et al., Chimia, vol. 40, pp. 318-321 (1986).
Sanada et al, "Chemical Abstracts", 108:131290r (1988).
Hayashi et al, "Chemical Abstracts", 106:326200u (1987).
Coffen David L.
Madan Pradeep B.
Schwartz Alan
Bond Robert T.
Gould George M.
Hoffmann-La Roche Inc.
Johnston George W.
Leon Bernard S.
LandOfFree
Glycidic acid ester and process of preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Glycidic acid ester and process of preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glycidic acid ester and process of preparation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-422334