Glyceryl valproates

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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Details

2604108, 560263, 514546, A61K 3122, C11C 302, C07C 6702

Patent

active

046543708

ABSTRACT:
Glycerides esterified with one or two moles of valproic acid and optionally esterified with fatty acids at the remaining hydroxy position(s) have been found to have the same useful therapeutic effect as valproic acid alone but without causing gastric irritation.

REFERENCES:
patent: 3686238 (1972-08-01), Zaffaroni
patent: 4423071 (1983-12-01), Chignac et al.
Meijer et al, Clinical and Pharmacological Aspects of Sodium Valproate (Epelim) in the Treatment of Epilepsy, Ed. N. J. Legg, published by McS Consultants, 1975, pp. 70-75.
Keil, Z. Physiol. Chem., 282, pp. 137-142 (1947), (Corresponds to Chem. Abstracts, 43:6164-65.)

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