Glycerophospholipids for the improvement of cognitive functions

Details Glycerophospholipids for the improvement of cognitive functions Glycerophospholipids for the improvement of cognitive functions

2011-05-03

2011-05-03

Wax, Robert A (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

C514S120000, C424S439000

Reexamination Certificate

active

07935365

ABSTRACT:
This invention provides a preparation comprising serine glycerophospholipids which comprise a mixture of serine glycerophospholipids comprising eicosapentaenoic acid (EPA) and serine glycerophospholipids comprising docosahexaenoic acid (DHA), wherein each such serine glycerophospholipid comprising EPA and each such serine glycerophospholipid comprising DHA has the formula (I):wherein R″ is serine; wherein one of R or R′ is acyl EPA or acyl DHA and the other of R or R′ is hydrogen or an acyl group; wherein the combined amount of EPA and DHA present in such mixture of serine glycerophospholipids constitutes 10-50% by weight of the total fatty acids content of the serine glycerophospholipids in said preparation; and wherein the mixture is not identical to naturally occurring human or mammalian brain PS.

REFERENCES:
patent: 5015483 (1991-05-01), Haynes et al.
patent: 5700668 (1997-12-01), De Ferra et al.
patent: 5750572 (1998-05-01), Bruzzese
patent: 5925669 (1999-07-01), Katz et al.
patent: 6005004 (1999-12-01), Katz et al.
patent: 6514973 (2003-02-01), Buchholz et al.
patent: 6541043 (2003-04-01), Lang
patent: 6645742 (2003-11-01), De Ferra et al.
patent: 2004/0120985 (2004-06-01), Geiss
patent: 2004/0234587 (2004-11-01), Sampalis
patent: 2005/0130937 (2005-06-01), Ben Dror et al.
patent: 2006/0241080 (2006-10-01), Dror et al.
patent: 2007/0160659 (2007-07-01), Platt et al.
patent: 2008/0085319 (2008-04-01), Dror et al.
patent: 2008/0085320 (2008-04-01), Dror et al.
patent: 2907778 (1979-08-01), None
patent: 199 43 198 (2000-07-01), None
patent: 199 43 198 (2001-03-01), None
patent: 0209037 (1987-01-01), None
patent: 0275224 (1993-07-01), None
patent: 0275005 (1993-08-01), None
patent: 0609078 (1994-01-01), None
patent: 0819760 (1998-01-01), None
patent: 1417211 (2007-05-01), None
patent: 2088750 (1996-08-01), None
patent: 03188088 (1991-08-01), None
patent: 06256179 (1994-09-01), None
patent: 06279311 (1994-10-01), None
patent: WO 92/21335 (1992-12-01), None
patent: WO 96/37200 (1996-11-01), None
patent: WO 97/39759 (1997-10-01), None
patent: WO 00/23546 (2000-04-01), None
patent: WO 01/84961 (2001-11-01), None
patent: WO 02/102394 (2002-12-01), None
patent: WO 2004/049907 (2004-06-01), None
patent: WO 2005/038037 (2005-04-01), None
Sampalis et al. Evaluation of the Effects of Neptune Krill Oil on the Management of Premenstrual Syndrome and Dysmenorrhea, Alternative Medicine Review, 8:2 (2003) pp. 171-179.
Hanahan et al. Complex Lipids, Annual Rev. Biochem., 32:215 (1963).
Office Action issued Dec. 26, 2007 in connection with U.S. Appl. No. 10/485,094, filed Jul. 15, 2004.
Preliminary Amendment filed Jan. 26, 2004 in connection with U.S. Appl. No. 10/485,094, filed Jul. 15, 2004.
Youdim et al. Essential fatty acids and the brain: possible health implications, Int. J. Devl Neuroscience, 18:383 (2000).
Kalmijn et al. Dietary Fat Intake and the Risk of Incident Dementia in the Rotterdam Study, Annals of Neurology, 42:5 (1997) pp. 776-782.
Edwards et al. Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients, Journal of Affective Disorders, 48:149-155 (1998).
Hosokawa et al. Conversion to Docosahexaenoic Acid-Containing Phosphatidylserine from Squid Skin Lecithin by Phospholipase D-Mediated Transphosphatidylation, J. Agric. Food Chem., 48:4550-4554 (2000).
Wiegand et al. Phospholipid Molecular Species of Frog Rod Outer Segment Membranes, Exp. Eye Res., 37:159-173 (1983).
Bell et al. Molecular Species Composition of the Major Diacyl Glycerophospholipids from Muscle, Liver, Retina and Brain of Cod (Gadus morhua), Lipids, 26:8 (1991) pp.565-573.
Henderson et al. Lipid Composition of the Pineal Organ from Rainbow Trout (Oncorhynchus mykiss), Lipids, 29:5 (1994) pp. 311-317.
Notice of Allowance issued Jul. 2, 2010 in connection with U.S. Appl. No. 11/414,150, filed Apr. 28, 2006.
U.S. Appl. No. 60/307,842, filed Jul. 27, 2001 (Sampalis).
Claims pending in Gai Ben Dror et al., U.S. Appl. No. 11/414,150, filed Apr. 28, 2006.
Claims pending in Gai Ben Dror et al., U.S. Appl. No. 11/872,440, filed Oct. 15, 2007.
Office Action issued May 15, 2007 in connection with U.S. Appl. No. 11/414,150, filed Apr. 28, 2006.
Office Action issued Jul. 6, 2007 in connection with U.S. Appl. No. 11/414,150, filed Apr. 28, 2006.
Final Office Action issued Jan. 15, 2008 in connection with U.S. Appl. No. 11/414,150, filed Apr. 28, 2006.
Advisory Action issued May 14, 2008 in connection with U.S. Appl. No. 11/414,150, filed Apr. 28, 2006.
Office Action issued Apr. 28, 2009 in connection with U.S. Appl. No. 11/414,150, filed Apr. 28, 2006.
Interview Summary issued Aug. 11, 2009 in connection with U.S. Appl. No. 11/414,150, filed Apr. 28, 2006.
Final Office Action issued Dec. 24, 2009 in connection with U.S. Appl. No. 11/414,150, filed Apr. 28, 2006.
Interview Summary issued May 11, 2010 in connection with U.S. Appl. No. 11/414,150, filed Apr. 28, 2006.
Office Action issued May 14, 2009 in connection with U.S. Appl. No. 11/872,440, filed Oct. 15, 2007.
Final Office Action issued Jan. 5, 2010 in connection with U.S. Appl. No. 11/872,440, filed Oct. 15, 2007.
Interview Summary issued May 12, 2010 in connection with U.S. Appl. No. 11/872,440, filed Oct. 15, 2007.
Notice of Allowance issued Jun. 3, 2010 in connection with U.S. Appl. No. 11/872,440, filed Oct. 15, 2007.
Jorissen et al. Safety of Soy-derived Phosphatidylserine in Elderly People, Nutritional Neurosciences, 2002 (5), pp. 337-343.
AMNI Phosphatidylserine Product Data, 1999, pp. 1-2.
International Search Report issued by the International Searching Authority on Mar. 25, 2010 in connection with International Appl. No. PCT/IL2009/000626.
Written Opinion of the International Searching Authority issued by the International Searching Authority (ISA/IL) in connection with International Application No. PCT/IL2009/000626, Mar. 25, 2010.
Office Action issued Mar. 16, 2010 in connection with U.S. Appl. No. 10/572,782, filed Nov. 8, 2006.
Yamane. Enzyme Engineering for Lipids, Proc. Sat. Forum, Sustainable Agriculture System in Asia, Nagoya: Jun. 2002, pp. 61-68.
European Patent Application Publication No. EP 1213294 A1, published Jun. 12, 2002.
Japanese Patent Publication No. 2002-241385, published Aug. 28, 2002 for Yakult Honsha Co. Ltd., and English translation.
Japanese Patent Publication No. 2001-354680, published Dec. 25, 2001 for NOF Corp., and English translation.
Japanese Patent Publication No. 2001-122884, published Aug. 5, 2001 for Yakult Honsha Co. Ltd., and English translation.
European Patent Application Publication No. EP 0922707 A1, published Jun. 16, 1999.
International Patent Application Publication No. WO 01/82902 A1, published Nov. 8, 2001.
Office Action issued Mar. 30, 2009 in connection with U.S. Appl. No. 10/572,782, filed Nov. 8, 2006.
Lekh Raj Juneja et al. Conversion of phosphatidylcholine to phosphatidylserine by various phospholipases D in the presence of L- or D-serine, Biochimica et Biophysica Acta, 1003 (1987), pp. 277-283.
Wu Wutong, Biochemistry 4thEdition, p. 149, and English translation.
International Patent Application Publication No. WO 03/088949 A1, published Oct. 30, 2003, Abstract only.
International Patent Application Publication No. WO 00/56869 A1, published Sep. 28, 2000.
International Search Report issued by the International Searching Authority on Aug. 29, 2005 in connection with International Application No. PCT/IL2004/000895.
International Preliminary Report on Patentability issued by the International Searching Authority on Mar. 27, 2006 in connection with International Application No. PCT/IL2004/000895.
Written Opinion of the International Searching Authority issued by the International Searching Authority (ISA/IL) in connection with International Application No. PCT/IL2004/000895, Aug. 31, 2005.
Inernational Search Report issued by the International Searching Authoirty on Mar. 25, 2010 in connection with International Application No. PCT/IL2009/000626.
Written Opinion of the International Searching Authority issued by the International Searching

Affiliated with

Also associated with

Rating

Glycerophospholipids for the improvement of cognitive functions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Glycerophospholipids for the improvement of cognitive functions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glycerophospholipids for the improvement of cognitive functions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2690107