Glycerophosphoinositol derivatives as modulators of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Reexamination Certificate

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C554S079000

Reexamination Certificate

active

07625883

ABSTRACT:
Optionally O-substituted glycero-phosphoinositol derivatives, their analogues and their salts wherein the substitutents: R′1, R′2, R2, R3, R4, R5, R6 have the described meaning, their synthesis and their pharmacological effect as modulators of the activation or over-stimulation of cPLA2.

REFERENCES:
patent: 0 100 499 (1984-02-01), None
patent: 0 496 474 (1992-07-01), None
patent: 2 517 310 (1983-06-01), None
patent: WO 91 06301 (1991-05-01), None
patent: WO 91/12256 (1991-08-01), None
patent: WO 95 05479 (1995-02-01), None
patent: WO 97/48381 (1997-12-01), None
Young et al. “Total Synthesis of the Four Stereoisomers of Dihexadecanoyl Phophatidylinositol and the Substrate Stereospecificity of Human Erythrocyte Membrane Phosphatidylinositol 4-Kinase” J. Med. Chem. 1990, vol. 33, pp. 641-646.
Burke et al. “Cooperativity and Binding in the Mechanism of Cytosolic Phospholipase A2” Biochemistry, 1995, vol. 34, pp. 15165-15174.
Berrie, C.P. et al, “Membrane transport and in vitro metabolism of the Ras cascade messenger, glycerophosphoinositol 4-phosphate” European Journal of Biochemistry, vol. 266, No. 2, Dec. 1999 pp. 413-419, XP001011370.
Brown, D.M. et al., “Phospholipids. Part V. The Hydrolysis of Glycerol 1-esters of myoinositol 1- and 2- Phosphate,” Journal of The Chemical Society, Nov. 1959, pp. 3547-3552, XP002171609.
Chemical Abstracts, vol. 075, No. 13, Sep. 27, 1971, Columbus, OH, US; abstract No. 088863, Klyashchitskii B. A. et al, Klyashchitskii B. A. et al., “Derivatives of asymmetrically substituted myoinositol. VI., Synthesis of 2, 3, 4, 5, 6- and 1, 2, 4, 5, 6-penta-O-benzyl-sn-glyceryl-phosphoryl)-sn-myo-inositol” XP002171809.
Corda D. et al., “Glycerophosphoinositols as potential markers of Ras-induced transformation and novel second messengers,” Anticancer Research, vol. 16, No. 3B, May 1996, pp. 1341-1350, XP001011369.
Morisaki, N. et al., “Phosphorylation of Unnatural Phosphatidylinositols with Phosphatidylinositol 3-Kinase” Tetrahedron, NL, Elsevier Science Publishers, Amsterdam, vol. 56, No. 17, Apr. 2000, pp. 2603-2614, XP0041974757.
Shirai, R. et al., “The Structural requirement of Phosphatidylinositols as substrate of Phosphatidylinositol 3- Kinase,” Tetrahedron Letters, NL, Elsevier Science Publishers, Amsterdam, vol. 40, No. 9, Feb. 26, 1999, pp. 1693-1696, XP004157168.
Shvets V.I. et al., “Rosolution of Asymmetrically Substituted Myoinositols into Optical Antipodes,” Tetrahedron., vol. 29, No. 2, 1973, pp. 331-340, XP002171610.
Young, R.C. et al., “Total synthesis of the four stereoisomers of dihexadecanoyl phosphatidylinositol and the substrate stereospecificity of human erythrocyte membrane phosphatidylinositol 4-kinase,” Journal of Medicinal Chemistry, vol. 33, No. 2, Feb. 1990 pp. 641-646, XP002171611.
Armandi-Burgermeister, E., et al. Suppression of cytokine synthesis integrin expression and chronic inflammation by inhibitors of cytosolic phospholipase A2, European Journal of Pharmocology, May 20, 1997, pp. 237-250, vol. 326, Elsevier Science B.V.
Berrie, C.P., et al., “Glycerophosphoinositol-4-phosphate in intracellular signalling” inBioactive Lipids, Vanderbock, Y.Y.. ed., 1998, pp. 229-237 Plenum Publishing.

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