Glycerol ester derivative

Details Glycerol ester derivative Glycerol ester derivative

2003-03-27

2008-05-13

Padmanabhan, Sreenivasan (Department: 1616)

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

C534S010000, C424S001210, C558S180000

Reexamination Certificate

active

07371877

ABSTRACT:
A compound represented by the following general formula (IA) or a salt thereof:wherein Ar1represents hydrogen atom or an aryl group having at least one iodine atom as a substituent; Ar2represents an aryl group having at least one iodine atom as a substituent; L1and L2independently represent a divalent bridging group of which main chain contains 6 or more carbon atoms; L3represents a single bond or a divalent bridging group of which main chain contains 1 to 6 carbon atoms and one oxygen atom; X represents a functional group containing at least one heteroatom, provided that, when L3is a single bond, X represents a functional group other than hydroxyl group. The compound can be used as a membrane component of liposomes, and the liposomes can be used as a contrast medium for X-ray radiography.

REFERENCES:
patent: 4873075 (1989-10-01), Longino et al.
patent: 6103216 (2000-08-01), Bakan et al.
patent: 0 037 583 (1981-10-01), None
Weichert J P et al: “Polyiodinated Triglyceride Analogs as Potential Computed Tomography Imaging Agents for the Liver” Journal of Medicinal Chemistry, American Chemical Society. Washington, US, vol. 38, No. 4, Feb. 17, 1995, pp. 636-646, XP001057012.
Weichert J P et al. : “Combined Hepatocyte-selective and Blood-Pool Contrast Agents for the CT Detection of Experimental Liver Tumors in Rabbits,” RADIOLOGY, vol. 216, No. 3, 2000, pp. 865-871, XP002244766.
K. Bhardwaj et al. : “Identification, Purification and Characterization of a Thermally Stable Lipase from Rice Bran. A New Member of the (Phospho) Lipase Family”, Plant Physiology, vol. 127, No. 4, 2001, pp. 1728-1738, XP002244767.
J. P . Weichert et al.. : “Potentia1 Tumor-or Organ-Imaging Agents.” Journal of Medicinal Chemistry, vol. 29, No. 12, 1986, pp. 2457-2465, XP002244768.
Database Caplus ′Online! Chemical Abstracts Service, Columbus, Ohio, US; 1986, J. P. Weichert et al. : “Polyiodinated Triglyceride Analogs As Potential Hepatic Imaging Agents” Database accession No. 1986: 530036, XP002244769.
Database Caplus ′Online! Chemical Abstracts Service, Columbus, Ohio, US; 2000 J. P. Weichert et al. : “Polyiodinated triglyceride lipid emulsions for use as hepatoselective contrast agents in CT: effects of physicochemical properties on biodistribution and imaging profiles” Database accession No. 2000: 205019 XP002244770.
Database Caplus ′Online! Chemical Abstracts Service, Columbus, Ohio, US; 1992 Schwendner S. W. et al. : “Potentia1 organ or tumor imaging agents” Database accession No. 1992:587410, XP002244771.
Database Medline ′On1 ine! US National Library of Medicine (NLM), Bethesda, MD, US; 1993 FF Knapp et al. : “Site-specific stable radioiodination of 1,2-Pal-3-IPPA: an agent for t he potentia1 clinical evaluation of pancreatic insufficiency by urine analysis” Database accession No. 93286735, XP002244772.
M-L Alcaraz et al.: “Synthesis and Properties of Photoactivatable Phospholipid Derivatives Designed To Probe the Membrane-Associate Domains of Proteins”. Journal of Organic Chemistry, vol. 61, 1996, pp. 192-201, XP002250373.
B. Corsico et al. : “Evidence for a central apolipoprotein A-I domain loosely bound to 1ipids in discoidal 1ipoproteins that us capable of penetrating the bi1ayer of phospholipid vesicles”. Journal of Biological Chemistry, vol. 276, No. 20, 2001, pp. 16978-16985, XP002250374.
Y. Ogawa et al. : “Regioselective photolabeling of glycoprotein A in membranes”. Chem. Eur. Journal, vol. 8, No. 8, 2002, pp. 1843-1849, XP002250375.

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