Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Transferases
Patent
1998-06-22
1999-07-06
Prouty, Rebecca E.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Transferases
435193, A61K 3845, C12N 910
Patent
active
059194502
ABSTRACT:
The invention provides a human glutathione S-transferase (GSTH) and polynucleotides which identify and encode GSTH. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating and preventing disorders associated with expression of GSTH.
REFERENCES:
Thier, R. et al., "Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes", Proc. Natl. Acad. Sci. USA, 90: 8576-8580 (1993).
Simula, T.P. et al., "Human glutathione S-transferase-expressing Salmonella typhimurium tester strains to study the activation/detoxification of mutagenic compounds: studies with halogenated compounds, aromatic amines and aflatoxin B.sub.1 ", Carcinogenesis, 14: 1371-1376 (1993).
Dirven, H.A.A.M., et al., "Involvement of Human Glutathione S-Transferase Isoenzymes in the Conjugation of Cyclophosphamide Metabolites with Glutathione", Cancer Res., 54: 6215-6220 (1994).
Kodym, R. et al., (Direct Submission), GenBank Sequence Database (Accession U80819), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1750199;GI 1750200).
Kodym, R. et al., (Direct Submission), GenBank Sequence Database (Accession U90313), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1899207; GI 1899208) May 1997.
Corley Neil C.
Hillman Jennifer L.
Shah Purvi
Bugalsky Gabriele E.
Incyte Pharmaceuticals Inc.
Price, Esq. Leanne C.
Prouty Rebecca E.
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