Glutathione S-transferase-activated compounds

Details Glutathione S-transferase-activated compounds Glutathione S-transferase-activated compounds

1993-10-01

1996-08-13

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, A61K 3800, C07K 5023

Patent

active

055456219

ABSTRACT:
Compounds of the formula: ##STR1## or the amides, esters or salts thereof, wherein: L is an electron withdrawing leaving group;
S.sup.x is S=O, O=S=O, S=NH, HN=S=O, Se=O, O=Se=O, Se=NH, HN=Se=O, S+R.sup.4 wherein R.sup.4 is alkyl (1-6 C), or O--C=O or HN--C=O;
each R of R.sup.1, R.sup.2 and R.sup.3 is independently H or a noninterfering substituent;
n is 0, 1 or 2;
Y is selected from the group consisting of ##STR2## wherein m is 1 or 2; and AA.sub.C is an amino acid linked through a peptide bond to the remainder of said compound of formula 1, are dislosed.
These compounds are useful prodrugs for selective treatment of target tissues which contain compatible glutathione S-transferase (GST) isoenzymes.

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