Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-11-25
2000-02-29
Eyler, Yvonne
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 435325, 435 6, 514 44, 536 232, 536 235, C12P 2106, C12N 1500, C12N 500, C07H 2104
Patent
active
060308095
ABSTRACT:
The invention provides a human new glutathione S-transferase (GSTS) and polynucleotides which identify and encode GSTS. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of GS.
REFERENCES:
Hillier, et al., (Direct Submission), Gen Bank Sequence Database (Accession No. AA291397), National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, 20894, Aug. 8, 1997.
Thier, R. et al., "Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes", Proc. Natl. Acad. Sci. USA, 90:8576-8580 (1993).
Simula, T.P. et al., "Human glutathione S-transferase-expressing Salmonella typhimurium tester strains to study the activation/detoxification of mutagenic compounds: studies with halogenated compounds, aromatic amines and aflatoxin B.sub.1 ", Carcinogenesis, 14:1371-1376 (1993).
Dirven H. A. et al., "Involvement of Human Glutathione S-Transferase Isoenzymes in the Conjugation of Cyclophosphamide Metabolites with Glutathione", Cancer Res., 54:6215-20 (1994).
Pemble, S.E. et al., (Direct Submission), GenBank Sequence Database (Accession 1911749), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, Mar. 27, 1997.
Pemble, S.E. et al., (Direct Submission), GenBank Sequence Database (Accession S83436), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, Mar. 27, 1997.
Corley Neil C.
Hillman Jennifer L.
Lal Preeti
Shah Purvi
Eyler Yvonne
Incyte Pharmaceuticals Inc.
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