Glutathione reductase for therapy and prophylaxis of aids

Details Glutathione reductase for therapy and prophylaxis of aids Glutathione reductase for therapy and prophylaxis of aids

2006-05-16

2006-05-16

Meller, Michael (Department: 1655)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Reexamination Certificate

active

07045323

ABSTRACT:
The present invention concerns the use of glutathione-reductase (GSSG reductase) for the preparation of a medicament for the treatment of HIV-infected patients, seropositive or already affected by AIDS, both for prophylactic and therapeutic use.

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Simon, Gaëlle, et al., “Valpoic acid reduces the intracellular level of glutathione and stimulates human immunodeficiency virus,”Chemico-Biological Interactions91:111-121, 1994.
Palamara, Anna T., et al., “Inhibition of Murine AIDS of Reduced Glutathione,”AIDS Research and Human Retroviruses12(14):1373-1381, 1996.
O'Donovan, Donough J., et al., “Gene Transfer of Mitochondrially Targeted Glutathione Reductase Protects H441 Cells from t-Butyl Hydroperoxide-Induced Oxidant Stresses,”Am. J. Respir. Cell. Mol. Biol.20:256-263, 1999.
Ansovini, R., et al., “In Vitro Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) by FOY and Glutathione Reductase,” AIDS Vaccine 2001 Conference, Philadelphia, PA., Sep. 5-8, 2001; Abstract/Poster 211. http://www.aidsvaccine2001.org/Pages/Abstract/10290.htm.

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