Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1995-06-07
1998-06-09
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
514 18, C07K 508, A61K 3806
Patent
active
057635706
ABSTRACT:
Compounds of the formula ##STR1## or the alkyl (1-6C), alkenyl (1-6C), or arylalkyl (7-12C) amides or salts including the cycloamido forms thereof;
REFERENCES:
patent: 4851388 (1989-07-01), Bright
patent: 4963263 (1990-10-01), Kauvar
patent: 5133866 (1992-07-01), Kauvar
patent: 5204241 (1993-04-01), Pero
patent: 5430045 (1995-07-01), Goldberg et al.
patent: 5599903 (1997-02-01), Kauvar et al.
Kasai et al. Glutamyl peptides of vigna radiata seeds. Phytochemistry, 25 (3), 679-682, 1986.
Ciaccio P.J. et al. "Modulation of Detoxification Gene Expression in Human Colon HT29 Cells by Glutathione-S-Transferase Inhibitors" Molecular Pharmacology 48:639-647 (1995).
Annual Meeting of the Canadian Society for Clinical Investigation and the Royal College of Physicians and Surgeons of Canda, Montreal, Quebec, Canada, Sep. 13-17, 1995, "Clinical and Investigative Medicine," vol. 18 (4 Suppl.) (1995), Cournoyer D. et al.
Morgan A. S. et al. "Isozyme-specific Glutathione S-Transferase Inhibitors Potentiate Drug Sensitivity in Cultured Human Tumor Cell Lines," Cancer Chemother. Pharmacol. 37:363-370 (1996).
Adang, et al. "The Glutathione-Binding Site in Glutathione S-Transferases, Investigation of the cysteinyl, glycyl and y-glutamyl domains" Biochem. J. 269:47-54 (1990).
Borch et al., J Med Chem (1991) 34:3044-3058.
Borch et al., J Med Chem (1987) 30:427-431.
Borch et al., J Med Chem (1984) 27:490-494.
Camble, et al., J. Chem. Soc.. "The Use of S-Benzylthiomethyl-L-cysteine in Peptide Synthesis: Synthesis of Glutathione and Homoglutathione" (1968) 7/1515:1219-1224.
Campling, et al., BR J. Cancer (1993) 68:327-335.
Castro, et al. "Differences Among Human Tumor Cells in the Expression of Glutathione Transferases and Other Glutathione-Linked Enzymes" Carcinogenesis, 11(9):1569-1576 (1990).
Castro, et al. Biochem J (1993) 292:371-377.
Chatterjee et al. Cancer Immunol Immunother 38:75-82 (1994).
Dermer, Biotechnology 12:320 (1994).
Fenselau, C. and P.B.W. Smith, High-Performance tandem mass spectrometry in metabolism studies, Xenobiotica, vol. 22, No. 9/10. Sep. 1992-Oct. 1992, pp. 1207-1219.
Flatgaard et al., Cancer Chemother. Pharmacol (1993) 33:63-70.
Held, et al. "Effect of Dimethyl Fumarate on the Radiation Sensitivity of Mammalian Cells in Vitro" Radiation Research 115:495-502 (1988).
Kasai et al., Phytochemistry ".gamma.-Glutamyl Peptides of Vigna Radiata Seeds" vol. 25, pp. 679-682.
Kauvar, et al. Biotechniques 8:204-209 (1990).
Ketterer, B. et al., in "Glutathione Conjugation: Mechanisms and Biological Significants": Sies, H., et al. eds. (1988) Academic Press, Lonon, pp. 74-137.
Lyttle et al., "Glutathione-S-Transferase Activates Novel Alkylating Agents," Journal of Medicinal Chemistry, 37(10):1501-1507 (1994).
Mannervik, et al. "Identification of Three Classes of Cytosolic Glutathione Transferase Common to Several Mammalian Species: Correlation Between Structural Data and Enzymatic Properties" Proc. Natl. Acad. Sci. USA, vol. 82:7202-7206 (1985).
Mannervik, et al. CRC Crit. Rev. Biochem 23:283-355 (1986).
Merck Manual, 15th Edition, Merck & Co., Rahway, NJ (1987) pp. 1120-1121.
Morris, Biochem. J. (1960) 76:349-353.
Mozer et al., "Purification and Characterization of Corn Glutathione S-Transferase", Biochemistry 22:1068-1072 (1983).
O'Dwyer et al. Cancer Res. (1991) 51:6059-6065.
O'Dwyer et al. J. NCI (1992) 84:264-267.
Principato et al., "Effects of Some S-Blocked Glutathione Derivatives n the Prevalent Glyoxalase II (a Form) of Rat Liver," Enzyme (1989) 41:175-180.
Puchalski, et al. "Expression of Recombinant Glutathione S-Transferase .pi., Ya, or Yb.sub.1 Confers Resistance to Alkylating Agents" Proc. Natl. Acad. Sci., USA 87:2443-2447 (1990).
Reieneman, P.,et al., J. Mol Biol (1992) 213:214-226.
Ricci, et al. "Detection of Glutathione Transferase Activity on Polyacrylamide Gels" Analytical Biochemistry 143:226-230 (1984).
Ripple et al. J. Urology (1993) 150:209-214.
Schisselbauer et al. "Characterization of Glutathione S-Transferase Expression in Lymphocytes From Chronic Lymphocytic Leukemia Patients" Cancer Research 50:3562-3568 (1990).
Sharer, J.E. et al., Formation, stability, and rearrangements of the glutathione conjugates of butadiene monoxide; evidence for the formation of stable surfurane intermediates, Chem. Res. Toxicol. (1991), 4(4), 430-6 CODEN: CRTOEC; ISSN: 0893-228X, 1991, pp. 434-435.
Sheh. et al. "Synthesis of Cyclic Peptide Homologs of Glutathione as Potential Antitumor Agents" Int. J. Peptide Protein Res. 35, 55-62 (1990).
Smith, et al. "Denitrosation of 1,3-Bis(2-chloroethyl)-1-nitrosourea by Class Mu Glutathione Transferases and Its Role in Cellular Resistance in Rat Brain Tumor Cells" Cancer Research 49:2621-2625 (1989).
Takeo, et al. "Binding Constants of Dextrans and Isomaltose Oligosaccharides to Dextran-Specific Myeloma Proteins Determined by Affinity Electrophoresis" The Journal of Immunology 121:2305-2310 (1978).
Tew, et al. "Ethacrynic Acid and Piriprost as Enhancers of Cytotoxicity in Drug Resistant and Sensitive Cell Lines" Cancer Research 48:3622-3625 (1988).
Vos, et al. "Differential Induction of Rat Hepatic Glutathione S-Transferase Isoenzymes by Hexachlorobenzene and Benzyl Isothiocyanate" Biochemical Pharmacology 37(6):1077-1082 (1988).
Waxman "Glutathione S-Transferases: Role in Alkylating Agent Resistance and Possible Target for Modulation Chemotherapy--A Review" Cancer Research 50:6449-6454 (1990).
Wiencke et al. "Human Glutathione S-Transferase Deficiency as a Market of Susceptibility to Epoxide-Induced Cytogenetic Damage" Cancer Research 50, 1585-1590 (1990).
Webster's II New Riverside University Dictionary, p. 849 (1988).
Kauvar Lawrence M.
Lyttle Matthew H.
Borin Michael
Terrapin Technologies, Inc.
Tsang Cecilia J.
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