Glutarimide antianxiety and antihypertensive agents

Details Glutarimide antianxiety and antihypertensive agents Glutarimide antianxiety and antihypertensive agents

1985-06-13

1986-09-16

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514234, 514255, 514278, 514321, 514322, 546 16, 546197, 546198, 546199, 544 6, 544 52, 544 70, 544105, 544230, 544353, C07D40512, A61K 31395

Patent

active

046123121

ABSTRACT:
Glutarimide derivatives of the formula which are useful antihypertensive and antianxiety agents ##STR1## wherein R.sub.1 and R.sub.2 each independently represent hydrogen, a 1 to 4 carbon alkyl, a 1 to 4 carbon alkoxy, halogen, nitro, hydroxy, SO.sub.3 H, SO.sub.2 NH.sub.2, and when R.sub.1 and R.sub.2 are taken together, form a fused phenyl group at the 1,2- or 3,4- positions, with the proviso that when R.sub.1 and R.sub.2 are identical they each represent a hydrogen, a 1 to 4 carbon alkyl, a 1 to 4 carbon alkoxy, hydroxy or a halogen group; A and B independently represent an oxo, a thio or an imino group having the formula --N(R.sub.6)-- wherein the R.sub.6 group is hydrogen or a 1 to 4 carbon alkyl group; R.sub.3 is a hydrogen, a 1 to 4 carbon alkyl or hydroxyethyl group; n is an integer of from 2 to 5; and R.sub.4 and R.sub.5 represent methyl groups or when taken together form a cyclopentane or cyclohexane ring; its enantiomers; and the pharmaceutically acceptable acid addition salts thereof.

REFERENCES:
patent: 2725386 (1955-11-01), Bovet et al.
patent: 3717634 (1973-02-01), Wu et al.
patent: 4182763 (1980-01-01), Casten et al.

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