Glutaramide diuretic agents

Details Glutaramide diuretic agents Glutaramide diuretic agents

1989-05-19

1991-07-09

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

5142375, 514255, 514259, 514269, 514311, 514319, 514331, 514365, 514381, 514396, 514406, 514408, 514427, 514438, 514450, 514471, 514529, 514530, 514533, 544159, 544163, 544165, 544225, 544283, 544335, 544336, 544391, 544400, 544406, 546168, 546172, 546175, 546205, 546226, 546233, 546336, 548200, 548204, 548236, 548247, 548248, 548252, 548342, 548352, 548356, 548482, 548486, 548491, 548537, 548561, 548568, 549 72, 549347, 549426, 549493, 560 41, 560106, 560107, 560119, 560122, 560125, 562450, 562501, 562504,

Patent

active

050306545

ABSTRACT:
A series of novel spiro-substituted glutaramide derivatives have been prepared, including the pharmaceutically acceptable salts thereof and bioprecursors therefor, wherein the spiro-substituent completes a 5- or 6-membered carbocycyclic ring and is located at the carbon atom adjacent to the carbamoyl group. These particular compounds are inhibitors of the neutral endopeptidase E.C.3.4.24.11 enzyme and are therefore useful in therapy as diuretic agents for the treatment of hypertension, heart failure, renal insufficiency and other disorders. Methods for preparing these compounds from known starting materials are provided.

REFERENCES:
patent: 4513009 (1985-04-01), Roques et al.
patent: 4749688 (1988-06-01), Haslanger et al.

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