Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1991-05-30
1993-03-09
Shippen, Michael L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
5142375, 514255, 514259, 514269, 514311, 514319, 514331, 514365, 514381, 514396, 514406, 514408, 514427, 514438, 514450, 514471, 514529, 514530, 514533, A61K 3121
Patent
active
051928000
ABSTRACT:
A series of novel spiro-substituted glutaramide derivatives have been prepared, including the pharmaceutically acceptable salts thereof and bioprecursors therefor, wherein the spiro-substituent completes a 5- or 6- membered carbocyclic ring and is located at the carbon atom adjacent to the carbamoyl group. These particular compounds are inhibitors of the neutral endopeptidase E.C.3,4.24.11 enzyme and are therefore useful in therapy as diuretic agents for the treatment of hypertension, heart failure, renal insufficiency and other disorders. Methods for preparing these compounds from known starting materials are provided.
REFERENCES:
patent: 4513009 (1985-04-01), Roques
patent: 4749688 (1988-06-01), Haslanger
Barnish Ian T.
Danilewicz John C.
James Keith
Samuels Gillian M. B.
Terrett Nicholas K.
Ginsburg Paul H.
Pfizer Inc.
Richardson Peter C.
Shippen Michael L.
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